Association of Genetic Polymorphism −670A>G in the Fas Gene and Serum Markers AST Platelet Ratio Index, AST/ALT with Significant Fibrosis and Cirrhosis in Chronic Hepatitis C
| Autor: | Akram Deghady, Wafaa Ahmed EL-Neanaey, Iman Diab, Alaa Abdou |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Liver Cirrhosis Male Pathology medicine.medical_specialty Cirrhosis Gastroenterology Chronic hepatitis Internal medicine medicine Humans Platelet Aspartate Aminotransferases fas Receptor Genetics (clinical) Aged Polymorphism Genetic medicine.diagnostic_test Platelet Count business.industry Alanine Transaminase General Medicine Odds ratio Hepatitis C Chronic Middle Aged medicine.disease Fas receptor Confidence interval Liver biopsy Female business Biomarkers Significant fibrosis |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 16:531-535 |
| ISSN: | 1945-0257 1945-0265 |
| Popis: | This study was carried out to evaluate the association of genetic polymorphism -670AG in the promoter of Fas gene as well as serum biomarkers aspartate aminotransferase (AST) platelet ratio index (APRI) and AST/alanine aminotransferase (ALT) with significant fibrosis and cirrhosis in chronic hepatitis C patients. Seventy-nine patients with chronic hepatitis C in addition to 80 age- and sex-matched healthy controls were evaluated for genetic polymorphism -670AG of Fas gene by polymerase chain reaction-restriction fragment length polymorphism and serum biomarkers APRI and AST/ALT in relation to significant fibrosis and cirrhosis diagnosed by liver biopsy.Genetic polymorphism -670AG in Fas gene was associated with significant liver fibrosis and cirrhosis. Heterozygous mutation was found in 11.4% of patients and 10% of controls, while homozygous mutation was found only in 7.6% of patients. Odds ratio (OR) was statistically not significant (OR=1.93, 95% confidence interval=0.76-4.92). Mean values of APRI and AST/ALT were significantly higher in patients with (F3-F4) compared with those with (F0-F2). (p-value0.001 for APRI and p=0.007 for AST/ALT). In addition, APRI showed a better sensitivity than AST/ALT for prediction of significant fibrosis.Genetic polymorphism -670AG of Fas gene was associated with significant fibrosis and cirrhosis in chronic hepatitis C patients. APRI and AST/ALT are independent predictors for significant fibrosis. APRI showed a better sensitivity than AST/ALT for prediction of significant fibrosis. Moreover, APRI can be used as an index to exclude liver cirrhosis without performing liver biopsy. |
| Databáze: | OpenAIRE |
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