199 Early predictors of bronchiectasis and trapped air severity in cystic fibrosis
| Autor: | M. Rosenfeld, Leonie A. Tepper, Daan Caudri, H.A.W.M. Tiddens |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
Study drug Bronchiectasis Inhalation business.industry Exhalation urologic and male genital diseases medicine.disease Cystic fibrosis Trapped air Anesthesia Pediatrics Perinatology and Child Health medicine Effective treatment Pediatrics Perinatology and Child Health business Mouthpiece |
| Zdroj: | Journal of Cystic Fibrosis. 12:S99 |
| ISSN: | 1569-1993 |
| DOI: | 10.1016/s1569-1993(13)60340-9 |
| Popis: | Objectives: For effective treatment of CF with inhaled drugs, efficient, easy to use devices are needed. This study was designed to assess time and practicability of Alpha-1-Antitrypsin (A1-PI(H)), (77mg/1.1ml) lung deposition in CF patients. Methods: Using the Respironics I-Neb AAD System. 15 mild to severe CF patients (FEV1: 34–101%) were included to inhale study drug in two inhalation modes: Target Inhalation Mode (TIM) and Tidal Breathing Mode (TBM). Conclusion: Total inhalation time was lower in TIM (3±0.5 min) than in TBM (4.5±2.1 min). Inhalation time and volume inhaled per breath were lower in TBM than in TIM. Subjects inhaled more deeply and slowly in TIM. Consequently, treatment time was longer and the number of breaths needed to deliver a similar dose was higher in TBM than in TIM. In both inhalation modes a high percentage of CF subjects rated their mouthpiece exhalation as “easy” and “very easy” (TIM: 80%, TBM: 100%). In total, 87% of the CF subjects classified their mouthpiece inhalation through in TBM as “easy” and “very easy” (TIM: 40%). For both inhalation modes a high percentage of CF subjects classified the use of the I-neb as “easy” and “very easy” (TIM: 71.5%, TBM: 86.7%). All CF patients were able to inhale the full dose in |
| Databáze: | OpenAIRE |
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