Childhood levels of immunoglobulins and mannan-binding lectin in relation to infections and allergy
| Autor: | H. K. Thórarinsdóttir, G J Arason, M. O. Leópoldsdóttir, T. Jónsson, Bjorn R. Ludviksson, T. Vikingsdottir, Helgi Valdimarsson, B. Árdal |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Immunoglobulin A
Adult Male Allergy Immunology Disease Biology Mannose-Binding Lectin Cohort Studies Recurrence medicine Hypersensitivity Humans Respiratory Tract Infections Mannan-binding lectin Respiratory tract infections Infant General Medicine bacterial infections and mycoses medicine.disease Otitis Media Otitis Immunoglobulin G Cohort biology.protein Female Disease Susceptibility medicine.symptom Cohort study |
| Zdroj: | Scandinavian journal of immunology. 61(5) |
| ISSN: | 0300-9475 |
| Popis: | Respiratory tract infections, allergies and otitis media are common problems in early childhood. Our aim was to evaluate in a longitudinal community-based cohort study the association between maturation of immunoglobulin (Ig) and mannan-binding lectin (MBL) responses and disease manifestations in the first 4 years of life. Sustained low levels of IgA proved the strongest single indicator of susceptibility for recurrent otitis media (P = 0.008) and respiratory tract infections (P = 0.02), and this condition was also associated with low production of IgG subclasses. About 7% of the cohort had sustained low levels of MBL ( |
| Databáze: | OpenAIRE |
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