SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

Autor: Maria Clara Saad Menezes, Luiz Fernando Ferraz da Silva, Gustavo Rosa Gameiro, Ėlodie Baron, Jean-Jacques Rouby, Diego Vinicius Santinelli Pestana, José Otávio Costa Auler
Přispěvatelé: Universidade de São Paulo (USP), Service d'Anesthésie réanimation [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Lung Diseases
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia
Viral
Immunology
ACE2
Autopsy
SARS-CoV-2 pneumonia
Review
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
03 medical and health sciences
Hypercoagulability
0302 clinical medicine
Immune system
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Immunopathology
Pandemic
medicine
Pathology
Humans
Pandemics
030304 developmental biology
0303 health sciences
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
Lung
Acute respiratory distress syndrome
SARS-CoV-2
business.industry
lcsh:Medical emergencies. Critical care. Intensive care. First aid
COVID-19
lcsh:RC86-88.9
biochemical phenomena
metabolism
and nutrition
medicine.disease
3. Good health
Pneumonia
medicine.anatomical_structure
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology
Carrier Proteins
business
Zdroj: Critical Care, Vol 25, Iss 1, Pp 1-13 (2021)
Critical Care
Critical Care, BioMed Central, 2021, 25, pp.53. ⟨10.1186/s13054-020-03399-z⟩
ISSN: 1364-8535
1466-609X
DOI: 10.1186/s13054-020-03399-z⟩
Popis: The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.
Databáze: OpenAIRE
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