Modafinil for treatment of fatigue in post-polio syndrome: a randomized controlled trial
| Autor: | L. S. Halstead, Mohammad Salajegheh, Olavo M. Vasconcelos, Olga A. Prokhorenko, Alexander H. Vo, Bahman Jabbari, Marinos C. Dalakas, Cara H. Olsen, William W. Campbell, K. F. Kelley, K. Livornese |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Flaccid paralysis Modafinil Severity of Illness Index law.invention Randomized controlled trial Double-Blind Method Post-polio syndrome law medicine Humans Treatment Failure Benzhydryl Compounds Fatigue Aged Aged 80 and over Cross-Over Studies business.industry virus diseases Muscle weakness Middle Aged medicine.disease Placebo Effect Symptomatic relief nervous system diseases Poliomyelitis Postpoliomyelitis Syndrome Physical therapy Quality of Life Central Nervous System Stimulants Female Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Neurology. 68(20) |
| ISSN: | 1526-632X |
| Popis: | I read with interest the article by Vasconcelos et al. on the use of modafinil for the treatment of fatigue in post-polio syndrome.1 Like many clinicians caring for patients with post-polio syndrome, the overall negative results and expanding list of past failures are disappointing. Poliomyelitis has recently been identified as a cause of muscle weakness in patients with West Nile virus (WNV) infection, and a syndrome of acute asymmetric flaccid paralysis (AFP) has been described in numerous patients.2 This acute asymmetric flaccid paralysis resembles that of the anterior horn cell poliomyelitis seen in polio victims and is often associated with disabling fatigue and frequently hinders physical therapy and rehabilitation efforts. I am unaware of any reported medication trials in patients with WNV-AFP for symptomatic relief of disabling fatigue. In the summer of 2003, WNV invaded Southern California and then dispersed to every county in the state.3,4 Shortly thereafter, in my community, we started seeing our first cases of WNV-induced neurologic complaints, including monoplegic patients. Following workup on the medical floors including serologies, CSF analysis, and electrodiagnostic studies, they … |
| Databáze: | OpenAIRE |
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