Preparation and Dosimetry Evaluation of a Carrier- Free 90Y Labeled DOTMP as a Promising Agent for Bone Marrow Ablation
| Autor: | Mohsen Mehrabi, Mohammad Ghannadi Maraghe, Simindokht Shirvani Arani, Ali Bahrami Samani, Nafise Salek, Sara Vosoghi |
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| Rok vydání: | 2018 |
| Předmět: |
Ablation Techniques
Biodistribution Carrier free Lutetium Radiation Dosage Models Biological 01 natural sciences 030218 nuclear medicine & medical imaging Mice 03 medical and health sciences Bone Marrow Ablation Organophosphorus Compounds 0302 clinical medicine Bone Marrow medicine Animals Dosimetry Tissue Distribution Yttrium Radioisotopes Radiology Nuclear Medicine and imaging Femur Rats Wistar Radioisotopes Pharmacology Reaction conditions Samarium 010405 organic chemistry Chemistry Radiochemistry 0104 chemical sciences medicine.anatomical_structure Absorbed dose Femur bone Bone marrow |
| Zdroj: | Current Radiopharmaceuticals. 11:116-122 |
| ISSN: | 1874-4710 |
| Popis: | Background and objective Skeletal uptake of 90Y-1,4,7,10-tetraazacyclododecane-1,4,7,10- tetramethylene-phosphonate (DOTMP) is used to deliver high doses of this radiopharmaceutical to the bone marrow. Methods In this research, carrier-free (c.f.) 90Y was obtained from an electrochemical 90Sr/90Y generator. The c.f. 90Y was mixed with 300 µL of DOTMP (20 mg/mL) and incubated under stirring conditions at room temperature for 45 min. Results The [90Y]Y-DOTMP that was obtained under optimized reaction conditions had high radiochemical purities (>98%). Moreover, the radiolabeled complex exhibited excellent stability at room temperature, as well as in human serum. The biodistribution studies in rats showed the favorable selective skeletal uptake with rapid clearance from the blood, albeit with insignificant accumulation of activity in other non-target organs for the radiolabeled complex. Also, the present work has utilized the Monte Carlo codes MCNP-4C to simulate the depth dose profile for 90Y in a mice femur bone and compared with that produced by 153Sm and 177Lu. Conclusion The results show that the absorbed dose produced by 90Y in the bone marrow is higher than 153Sm and 177Lu per 1MBq of the injected activity. |
| Databáze: | OpenAIRE |
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