Autoimmune reactions in patients with M-component and peripheral neuropathy
| Autor: | W. Trojaborg, Erik Hippe, T. Staehelin Jensen, Viggo Jønsson, Henrik Daa Schrøder, M. M. Hansen |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Plasma cell dyscrasia Immunoglobulins Connective tissue Autoimmunity medicine.disease_cause Immunoglobulin D Internal Medicine medicine Humans Autoantibodies biology business.industry Autoantibody Blood Proteins Middle Aged medicine.disease Treatment Outcome medicine.anatomical_structure Peripheral neuropathy Immunology biology.protein Female Endoneurium business Monoclonal gammopathy of undetermined significance Demyelinating Diseases |
| Zdroj: | Jønsson, V, Schrøder, H D, Trojaborg, W, Jensen, T S, Hippe, E & Mørk Hansen, M 1992, ' Autoimmune reactions in patients with M-component and peripheral neuropathy ', Journal of Internal Medicine, vol. 232, no. 2, pp. 185-91 . University of Southern Denmark |
| ISSN: | 1365-2796 0954-6820 |
| Popis: | A study of 17 patients with autoimmune axonal or demyelinating peripheral neuropathy in combination with M-component is described. The M-component was associated with MGUS (monoclonal gammopathy of undetermined significance) in 12 patients, CLL in one patient, Waldenström's disease in one patient, and myeloma in three patients. Immunohistological examination with direct and indirect fluorescence showed binding of antibodies to nerve structures of the same class and light chain as seen in the M-component. In five cases of IgM M-component, the demyelinating neuropathy was caused by binding of the IgM M-protein and complement C3b to myelin-associated glycoproteins (MAG). In 12 cases with axonal neuropathy, binding of IgG to the connective tissue of the peri- and endoneurium was found in 50% of cases, IgM in five cases, and IgD in one case. None of the patients had central nervous system (CNS) symptoms. The clinical and therapeutic difficulties are discussed; only two patients with an acute course responded to immunosuppression. A marked co-expression of other autoimmune phenomena is interpreted in the light of cross-reactions between the autoantibody and similar tissue autoantigens. |
| Databáze: | OpenAIRE |
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