Consequences of Puberty on Efficacy of Intraocular Pressure-Lowering Drugs in Male Dutch-Belted Rabbits
| Autor: | Carol B. Toris, Kingsley C. Okafor, Shan Fan, Robin High, Dhirendra P. Singh, Cassandra L. Hays |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Intraocular pressure genetic structures medicine.medical_treatment Volume 1: Glaucoma IOP Neuroprotection and Devices Timolol 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Prepuberty medicine Sexual maturity Animals Pharmacology (medical) Sexual Maturation Latanoprost Saline Antihypertensive Agents Intraocular Pressure Pharmacology business.industry Aqueous flow eye diseases Ophthalmology 030104 developmental biology chemistry Anesthesia 030221 ophthalmology & optometry Ocular Hypertension sense organs Rabbits Ophthalmic Solutions business Acetazolamide medicine.drug |
| Zdroj: | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 34(1-2) |
| ISSN: | 1557-7732 |
| Popis: | Purpose: To investigate the changes in intraocular pressure (IOP), aqueous flow, and outflow facility, as well as efficacy of IOP-lowering drugs before and after sexual development in rabbits. Methods: Male Dutch-belted rabbits were studied at night between the ages of 8 and 44 weeks. During these times, body weight, testicular volume, and serum testosterone were measured to monitor sexual maturity. Ocular measurements included anterior chamber depth, central corneal thickness, IOP, aqueous flow, and outflow facility. Systemic acetazolamide or topical timolol, latanoprost, or saline were administered pre- and postpuberty to assess drug effects on these parameters. Results: Body weight, testicular volume, and serum testosterone increased until 28 weeks of age. IOP increased during prepuberty (R(2) = 0.49, P = 0.003), dropped significantly during puberty, rising again immediate postpuberty, and changing little thereafter. Postpuberty compared with prepuberty found higher IOP (P |
| Databáze: | OpenAIRE |
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