National post-market surveillance assessment of veterinary medicines in Korea during the past decade
| Autor: | Sungwon Park, Seonjong Yun, Mi Young Jeong, Dae Gyun Kim, JeongWoo Kang, Kwang-jick Lee, Hae-Chul Park, Yang ho Jang, Akil Hossain, Kyunghun Jeong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
Drug medicine.medical_specialty Veterinary medicine Veterinary Drugs Quality Assurance Health Care medicine.drug_class media_common.quotation_subject 030231 tropical medicine Antibiotics Alternative medicine Postmarketing surveillance 01 natural sciences 03 medical and health sciences 0302 clinical medicine 010608 biotechnology Republic of Korea Product Surveillance Postmarketing Medicine Good manufacturing practice media_common lcsh:Veterinary medicine General Veterinary business.industry Spiramycin Quality control General Medicine Post-market surveillance assay lcsh:SF600-1100 business Research Article medicine.drug |
| Zdroj: | BMC Veterinary Research, Vol 13, Iss 1, Pp 1-8 (2017) BMC Veterinary Research |
| ISSN: | 1746-6148 |
| DOI: | 10.1186/s12917-017-1054-z |
| Popis: | Background Veterinary medicines have been widely used for the prevention and treatment of diseases, growth promotion, and to promote feeding efficacy in livestock. As the veterinary medicine industry has steadily grown, it is crucial to set up a baseline for the quality of medicine as well as the insufficiency or excessiveness of the active ingredients in drug products to ensure the compliance, safety and efficacy of these medicines. Thus, the 10 years data of post-marketing quality control study was summarized to determine the rate and extent of non-compliance of these medicines and to establish baseline data for future quality control measures of veterinary medicine. Results In this study, 1650 drugs for veterinary use were collected per year from each city and province in Korea and analysed for the quantity of active ingredients according to the “national post-market surveillance (NPMS) system” over the past decade. The NPMS assessment was performed using liquid and gas chromatography, titration, UV/Vis spectrophotometry, and bioassays. A total of 358 cases were deemed noncompliant, with the average noncompliance rate for all medicine types being 2.0%. The average noncompliance rates for antibiotics, biologics and other chemical drugs except antibiotics (OCD) were 1.1%, 1.2%, and 3.0%, respectively. The first leading cause for noncompliant products was insufficient quantity of major ingredients (283 cases), and the second leading cause was the existence of excess amount of active ingredients (60 cases). Tylosin, spiramycin, ampicillin, tetracyclines and penicillins were most frequently found to be noncompliant among antibiotics. Among the OCD, the noncompliance was found commonly in vitamin A. Conclusion The overall trend presented gradually decreasing violation rates, suggesting that the quality of veterinary medicines has improved. Consistent application of the NPMS assessment and the establishment of the Korea Veterinary Good Manufacturing Practice (KVGMP) will help to maintain the good quality of medicine. |
| Databáze: | OpenAIRE |
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