Synthesis, biological assays and QSAR studies of N-(9-benzyl-2-phenyl-8-azapurin-6-yl)-amides as ligands for A1 adenosine receptors
| Autor: | Ilaria Massarelli, Michele Leonardi, Daniele Pietra, Anna Maria Paola Bianucci, Osele Ciampi, Irene Giorgi, Giuliana Biagi, Alice Borghini |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Quantitative structure–activity relationship
Receptor Adenosine A2A Stereochemistry Clinical Biochemistry Pharmaceutical Science Adenosine A3 Receptor Antagonists Quantitative Structure-Activity Relationship Ether Adenosine A1 Receptor Antagonists Ligands Biochemistry Chemical synthesis chemistry.chemical_compound Drug Discovery Phenyl group Moiety Animals 2-Phenyl-9-benzyl-8-azapurines Molecular Biology chemistry.chemical_classification Bicyclic molecule Chemistry Receptor Adenosine A1 QSAR Organic Chemistry Receptor Adenosine A3 Aromatic amine Classification Adenosine receptor Adenosine A2 Receptor Antagonists Rats Kinetics 2-Phenyl-9-benzyl-8-azapurines Adenosine receptor ligands Classification QSAR regression Purines Molecular Medicine Adenosine receptor ligands |
| Popis: | 2-Phenyl-9-benzyl-8-azapurines, bearing at the 6 position an amido group interposed between the 8-azapurine moiety and an alkyl or a substituted phenyl group, have been synthesised and assayed as ligands for adenosine receptors. All the compounds show high affinity for the A 1 adenosine receptor, and many of them also show a good selectivity for A 1 with respect to A 2A and A 3 adenosine receptors. Based on the quite rich library containing such compounds and relevant biological data, QSAR models, able to rationalise the results and to give a quantitative estimate of the observed trends were also developed. The obtained models can assist in the design of new compounds selectively active on A 1 adenosine receptor. |
| Databáze: | OpenAIRE |
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