Acute kidney injury after orthotopic liver transplantation
| Autor: | N. Gritsi-Gerogianni, K. Sgourou, Chrysostomos Dimitriadis, G. Imvrios, C. Kydona, Ioannis Fouzas, A. Karapanagiotou, T. Giasnetsova |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Urology Kaplan-Meier Estimate Liver transplantation urologic and male genital diseases law.invention chemistry.chemical_compound law Risk Factors Medicine Humans Renal replacement therapy Risk factor Retrospective Studies Mechanical ventilation Transplantation Creatinine Chi-Square Distribution Greece business.industry Mortality rate Incidence Acute kidney injury Acute Kidney Injury Length of Stay Middle Aged medicine.disease Intensive care unit Respiration Artificial Surgery Liver Transplantation Renal Replacement Therapy Intensive Care Units surgical procedures operative Logistic Models Treatment Outcome chemistry Female business Biomarkers |
| Zdroj: | Transplantation proceedings. 44(9) |
| ISSN: | 1873-2623 |
| Popis: | Acute kidney injury (AKI), one of the most frequent complications in the early period after liver transplantation, causes serious obstacles in the management of these patients affecting their outcomes. We studied retrospectively 79 subjects who underwent orthotopic liver transplantation (OLT). AKI was defined as an elevation of serum creatinine 1.5 times above baseline or an absolute serum creatinine level > 2 mg/dL. Our aim was to analyze the incidence, correlation with prior renal impairment, outcomes of AKI after OLT. Twenty-two patients (29.3%) developed AKI after OLT with 31.81% of the requiring renal replacement therapy. Among patients with AKI the duration of mechanical ventilation was prolonged (P = .001), length of stay in the intensive care unit was greater (P = .001), infections were more common (P = .016), and 30-day and 1-year mortality rates higher (P = .018). Logistic regression analysis showed post-OLT AKI to be an independent risk factor for 1-year mortality after OLT. |
| Databáze: | OpenAIRE |
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