Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract
| Autor: | Raimundo F. Araújo Júnior, Pedro Ros Petrovick, Ibson L. Lyra, Tatiane Pereira de Souza, Luiz Alberto Lira Soares, Aurigena Antunes de Araújo Ferreira, Silvana Maria Zucolotto Langassner, Gerlane Coelho Bernardo Guerra, Cínthia Raquel da Costa Porto |
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| Rok vydání: | 2013 |
| Předmět: |
Leukocyte migration
Phyllanthus medicine.drug_class Analgesic lcsh:RS1-441 Inflammation Pharmacology Anti-inflammatory lcsh:Pharmacy and materia medica Pharmacology Toxicology and Pharmaceutics(all) chemistry.chemical_compound medicine General Pharmacology Toxicology and Pharmaceutics antinociception standardization biology business.industry Euphorbiaceae biology.organism_classification anti-inflammation Carrageenan Nociception chemistry medicine.symptom business Phyllanthus niruri |
| Zdroj: | Revista Brasileira de Farmacognosia, Volume: 23, Issue: 1, Pages: 138-144, Published: 01 FEB 2013 Revista Brasileira de Farmacognosia, Vol 23, Iss 1, Pp 138-144 (2013) Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN Revista Brasileira de Farmacognosia v.23 n.1 2013 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| ISSN: | 0102-695X |
| DOI: | 10.1590/s0102-695x2013000100019 |
| Popis: | Phyllanthus niruri L., Euphorbiaceae, spray-dried standardized extract was studied for its anti-inflammatory and antinociceptive activities in adult albino rats and mice. The anti-inflammatory effect of spray-dried standardized extract was observed in carrageenan-induced paw edema and thioglycolate-induced leukocyte migration, while antinociceptive effects were observed using Randall & Selitto, tail flick, and hot plate tests. This study showed that intraperitoneal spray-dried standardized extract at 100, 200, 800, or 1600 mg/kg reduced the vascular response in the inl ammatory process of paw edema induced by 1% carrageenan. Oral spray-dried standardized extract at 100 or 200 mg/kg inhibited leukocyte migration to the site of inl ammation induced by 3% thioglycolate. In rats, at 100 and 200 mg/kg intraperitoneally, the extract exhibited a marked peripheral analgesic effect in a Randall & Selitto assay and showed signii cant central analgesic activity in a hot plate and tail flick assay. In conclusion, this study suggested that Phyllanthus niruri spray-dried standardized extract has potent inl ammatory and antinociceptive activities and that these activities are not modii ed by standard drying process, making it feasible to use the dry extract standardized to obtain a phytotherapic preparation and thus validating its use for the treatment of pain and inl ammation disorders Keywords: antinociception, anti-inflammation, Phyllanthus niruri, standardization |
| Databáze: | OpenAIRE |
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