Neuroanatomy of comorbid schizophrenia and learning disability: a controlled study
| Autor: | T. L. Sanderson, Jjk Best, Gillian A. Doody, D. G. Cunningham Owens, E. C. Johnstone |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Adolescent Population Comorbidity Audiology Hippocampus Central nervous system disease Intellectual Disability medicine Humans Risk factor education Psychiatry Analysis of Variance education.field_of_study Learning Disabilities business.industry Brain Cognition General Medicine Middle Aged Amygdala medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Scotland Schizophrenia Case-Control Studies Learning disability Female medicine.symptom business Neuroanatomy |
| Zdroj: | The Lancet. 354:1867-1871 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(99)01049-1 |
| Popis: | 1867 Summary Background Reasons for the higher frequency of schizophrenia in learning-disabled populations are uncertain. We investigated the neuroanatomical basis for this phenomenon by structural magnetic resonance imaging (MRI) in patients with learning disability and schizophrenia, learning-disabled patients, and patients with schizophrenia. Methods Age-matched and sex-matched patients with learning disability (20 cases), schizophrenia (25), and both disorders (23) underwent MRI scans of the brain. Whole brain areas and specific regions of interest were examined. 29 normal controls were also scanned. FIndings The scans of the group with both disorders were closely similar to those of the schizophrenic group, in terms of both general structures and the structure of the amygdalahippocampus. However, the amygdala-hippocampus was significantly smaller on both sides than that of normal controls (left 4·1 vs 4·5 cm 3 , p=0·011; right 4·2 vs 4·99 cm 3 , p |
| Databáze: | OpenAIRE |
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