Regulation of zebrafish sleep and arousal states: current and prospective approaches
| Autor: | David A. Prober, Cindy N. Chiu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Cognitive Neuroscience
Neuroscience (miscellaneous) Review Article Biology lcsh:RC321-571 Arousal 03 medical and health sciences Cellular and Molecular Neuroscience neuromodulator 0302 clinical medicine Neurochemical arousal Zebrafish (Danio rerio) Animals Humans sleep lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Zebrafish 030304 developmental biology 0303 health sciences Drug screens Optical transparency biology.organism_classification zebrafish Sleep in non-human animals Sensory Systems Orexin Structure and function Circadian Rhythm orexin hypocretin Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Neural Circuits Frontiers in Neural Circuits, Vol 7 (2013) |
| ISSN: | 1662-5110 |
| Popis: | Every day, we shift among various states of sleep and arousal to meet the many demands of our bodies and environment. A central puzzle in neurobiology is how the brain controls these behavioral states, which are essential to an animal’s well-being and survival. Mammalian models have predominated sleep and arousal research, although in the past decade, invertebrate models have made significant contributions to our understanding of the genetic underpinnings of behavioral states. More recently, the zebrafish has emerged as a promising model system for sleep and arousal research. Here we review experimental evidence that the zebrafish, a diurnal vertebrate, exhibits fundamental behavioral and neurochemical characteristics of mammalian sleep and arousal. We also propose how specific advantages of the zebrafish can be harnessed to advance the field. These include tractable genetics to identify and manipulate molecular and cellular regulators of behavioral states, optical transparency to facilitate in vivo observation of neural structure and function, and amenability to high-throughput drug screens to discover novel therapies for neurological disorders. |
| Databáze: | OpenAIRE |
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