52 Genetic Loci Influencing Myocardial Mass
| Autor: | Alan F. Wright, Cisca Wijmenga, Bruno H. Stricker, Peter W. Macfarlane, Edward G. Lakatta, Uwe Völker, Lenore J. Launer, Olli T. Raitakari, Stephan B. Felix, Toshiko Tanaka, Osorio Meirelles, Phil Barnett, Thomas Meitinger, Albert Hofman, Bosco Trinh, Tamara B. Harris, Peter M. Okin, Axel Visel, Teresa Nutile, Claudia T. Silva, Harry Campbell, Ilja M. Nolte, M. Fabiola Del Greco, Terho Lehtimäki, Shih-Jen Hwang, Alicia Lundby, Kamil Slowikowski, Luigi Ferrucci, Joshua C. Bis, Jerome I. Rotter, Nona Sotoodehnia, Sebastian Schafer, Igor Rudan, Ozren Polasek, Vinicius Tragante, Kenneth Rice, Connie R. Bezzina, Siegfried Perz, Aravinda Chakravarti, Paul I.W. de Bakker, Jared W. Magnani, Xinchen Wang, Yigal M. Pinto, Carsten Oliver Schmidt, Marcus Dörr, Peter P. Pramstaller, Jobanpreet Sehmi, Susan R. Heckbert, Richard B. Devereux, Jesper V. Olsen, Sheila Ulivi, Shane Neph, Peter M. Visscher, James F. Wilson, Alexander Nord, Tim D. Spector, Stefan Kääb, Elsayed Z. Soliman, Weihua Zhang, Lin Y. Chen, Pim van der Harst, Veronique Vitart, Anna F. Dominiczak, Mark Eijgelsheim, Pieter A. Doevendans, Josef M. Penninger, Jaspal S. Kooner, Georg Vogler, Patricia B. Munroe, Soumya Raychaudhuri, Christian Gieger, Harold Snieder, Annamaria Iorio, Caroline Hayward, Yalda Jamshidi, Mika Kähönen, Jessica van Setten, Wilko Spiering, Ian Ford, Andrew A. Hicks, John C. Chambers, Joel N. Hirschhorn, Matthew T. Maurano, Niek Verweij, Maria Grazia Pilia, Rolf Bodmer, Vilmundur Gudnason, Ben A. Oostra, Megan V. Cannon, Nilesh J. Samani, Bruce H. R. Wolffenbuttel, Annette Peters, David Schlessinger, Daniel Levy, J. Wouter Jukema, Malou van den Boogaard, Brendan M. Buckley, Arne Pfeufer, Michiel E. Adriaens, Rossella Sorice, Matthias Heinig, Jian Yang, Norbert Hubner, Stefania Bandinelli, André G. Uitterlinden, Hans L. Hillege, Martina Müller-Nurasyid, Andres Metspalu, Eric Haugen, Laurie A. Boyer, Ronald P. Stolk, Gonçalo R. Abecasis, Dan E. Arking, Manolis Kellis, Ishminder K. Kooner, Leo-Pekka Lyytikäinen, Dena G. Hernandez, Dirk J. van Veldhuisen, Len A. Pennacchio, Kasper Lage, Gianfranco Sinagra, Bruce M. Psaty, Christopher Newton-Cheh, Cornelia M. van Duijn, Stefania Nappo, Dalit May, Paolo Gasparini, Elizabeth J. Rossin, Rudolf A. de Boer, Alessandro P Delitala, Tõnu Esko, John A. Stamatoyannopoulos, Aaron Isaacs, Kathleen F. Kerr, Sian Tsung Tan, Tune H. Pers, Serena Sanna, Melanie Waldenberger, Marina Ciullo, Jorma Viikari, Vincent M. Christoffels, Bram P. Prins, Alvaro Alonso, Sandosh Padmanabhan, Harm-Jan Westra, Moritz F. Sinner, Albert V. Smith, Kirill V. Tarasov, Konstantin Strauch, Wiek H. van Gilst, Christian X. Weichenberger, Lude Franke, Folkert W. Asselbergs, Herman H W Silljé, Jan A. Kors, Irene Mateo Leach, Karl Andersen, Ivana Kolcic, Stella Trompet, Silvia Naitza |
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| Přispěvatelé: | Broad Institute of MIT and Harvard, Raychaudhuri, Soumya, Sciences, RS: FSE MaCSBio, RS: FPN MaCSBio, RS: FHML MaCSBio, Biochemie, RS: CARIM - R1.06 - Genetic Epidemiology and Genomics of cardiovascular diseases, Maastricht Centre for Systems Biology, Fysiologie, RS: Carim - B01 Blood proteins & engineering, Graduate School, ANS - Cellular & Molecular Mechanisms, ANS - Neuroinfection & -inflammation, AGEM - Endocrinology, metabolism and nutrition, Medical Biology, ACS - Heart failure & arrhythmias, ARD - Amsterdam Reproduction and Development, Intensive Care Medicine, Other Research, Cardiology, Ophthalmology, ACS - Amsterdam Cardiovascular Sciences, Center of Experimental and Molecular Medicine, AII - Inflammatory diseases, AII - Infectious diseases, ACS - Pulmonary hypertension & thrombosis, Gastroenterology and Hepatology, Experimental Immunology, Erasmus MC other, Epidemiology, Public Health, Medical Informatics, Clinical Genetics, Internal Medicine, Cardiovascular Centre (CVC), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Stem Cell Aging Leukemia and Lymphoma (SALL), Life Course Epidemiology (LCE), Groningen Kidney Center (GKC), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), van der Harst, Pim, van Setten, Jessica, Verweij, Niek, Vogler, Georg, Franke, Lude, Maurano, Matthew T., Wang, Xinchen, Mateo Leach, Irene, Eijgelsheim, Mark, Sotoodehnia, Nona, Hayward, Caroline, Sorice, Rossella, Meirelles, Osorio, Lyytikäinen, Leo Pekka, Polašek, Ozren, Tanaka, Toshiko, Arking, Dan E., Ulivi, Sheila, Trompet, Stella, Müller Nurasyid, Martina, Smith, Albert V., Dörr, Marcu, Kerr, Kathleen F., Magnani, Jared W., Fabiola, Del Greco M., Zhang, Weihua, Nolte, Ilja M., Silva, Claudia T., Padmanabhan, Sandosh, Tragante, Viniciu, Esko, Tõnu, Abecasis, Gonçalo R., Adriaens, Michiel E., Andersen, Karl, Barnett, Phil, Bis, Joshua C., Bodmer, Rolf, Buckley, Brendan M., Campbell, Harry, Cannon, Megan V., Chakravarti, Aravinda, Chen, Lin Y., Delitala, Alessandro, Devereux, Richard B., Doevendans, Pieter A., Dominiczak, Anna F., Ferrucci, Luigi, Ford, Ian, Gieger, Christian, Harris, Tamara B., Haugen, Eric, Heinig, Matthia, Hernandez, Dena G., Hillege, Hans L., Hirschhorn, Joel N., Hofman, Albert, Hubner, Norbert, Hwang, Shih Jen, Iorio, Annamaria, Kähönen, Mika, Kellis, Manoli, Kolcic, Ivana, Kooner, Ishminder K., Kooner, Jaspal S., Kors, Jan A., Lakatta, Edward G., Lage, Kasper, Launer, Lenore J., Levy, Daniel, Lundby, Alicia, Macfarlane, Peter W., May, Dalit, Meitinger, Thoma, Metspalu, Andre, Nappo, Stefania, Naitza, Silvia, Neph, Shane, Nord, Alex S., Nutile, Teresa, Okin, Peter M., Olsen, Jesper V., Oostra, Ben A., Penninger, Josef M., Pennacchio, Len A., Pers, Tune H., Perz, Siegfried, Peters, Annette, Pinto, Yigal M., Pfeufer, Arne, Pilia, Maria Grazia, Pramstaller, Peter P., Prins, Bram P., Raitakari, Olli T., Rice, Ken M., Rossin, Elizabeth J., Rotter, Jerome I., Schafer, Sebastian, Schlessinger, David, Schmidt, Carsten O., Sehmi, Jobanpreet, Silljé, Herman H. W., Sinagra, Gianfranco, Sinner, Moritz F., Slowikowski, Kamil, Soliman, Elsayed Z., Spector, Timothy D., Spiering, Wilko, Stamatoyannopoulos, John A., Stolk, Ronald P., Strauch, Konstantin, Tan, Sian Tsung, Tarasov, Kirill V., Trinh, Bosco, Uitterlinden, Andre G., van den Boogaard, Malou, van Duijn, Cornelia M., van Gilst, Wiek H., Viikari, Jorma S., Visscher, Peter M., Vitart, Veronique, Völker, Uwe, Waldenberger, Melanie, Weichenberger, Christian X., Westra, Harm Jan, Wijmenga, Cisca, Wolffenbuttel, Bruce H., Yang, Jian, Bezzina, Connie R., Munroe, Patricia B., Snieder, Harold, Wright, Alan F., Rudan, Igor, Boyer, Laurie A., Asselbergs, Folkert W., van Veldhuisen, Dirk J., Stricker, Bruno H., Psaty, Bruce M., Ciullo, Marina, Sanna, Serena, Lehtimäki, Terho, Wilson, James F., Bandinelli, Stefania, Alonso, Alvaro, Gasparini, Paolo, Jukema, J. Wouter, Kääb, Stefan, Gudnason, Vilmundur, Felix, Stephan B., Heckbert, Susan R., de Boer, Rudolf A., Newton Cheh, Christopher, Hicks, Andrew A., Chambers, John C., Jamshidi, Yalda, Visel, Axel, Christoffels, Vincent M., Isaacs, Aaron, Samani, Nilesh J., de Bakker, Paul I. W. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biological functions Qrs Electrocardiogram Genetic Association Study Heart Failure Left Ventricular Hypertrophy Candidate gene Cardiac & Cardiovascular Systems heart failure Genome-wide association study ELECTROCARDIOGRAM 030204 cardiovascular system & hematology SCN5A gene Gene locus DISEASE Muscle hypertrophy In vivo study 0302 clinical medicine Sodium channel Nav1.5 REGULATORY DNA Sodium channel Nav1.8 Cardiac muscle CARDIAC-HYPERTROPHY Priority journal RISK Genetics Validation study Heart Genetic parameters Reliability Chromatin left ventricular hypertrophy GENOME Drosophila melanogaster Phenotype medicine.anatomical_structure 1117 Public Health And Health Services genetic association study Cardiology cardiovascular system HEART Functional assessment Histone modification Cardiology and Cardiovascular Medicine Genetic trait Life Sciences & Biomedicine Human medicine.medical_specialty Cardiomegaly Locus (genetics) Major clinical study electrocardiogram European QRS 1102 Cardiovascular Medicine And Haematology Article 03 medical and health sciences QRS complex LEFT-VENTRICULAR HYPERTROPHY Internal medicine Journal Article medicine Mus musculus Protein binding Animals Humans SCN10A gene VOLTAGE Cardiovascular parameters Heart ventricle hypertrophy Science & Technology Human genome Animal business.industry MORTALITY In vitro study ta3121 medicine.disease DYSFUNCTION 030104 developmental biology Gene identification Cardiovascular System & Hematology Genetic Loci Heart failure Expression quantitative trait loci Genetic association Meta analysis (topic) Cardiovascular System & Cardiology Genetic variability Transcription factor Myocardial mass business |
| Zdroj: | Elsevier Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier Science Journal of The American College of Cardiology Journal of the American College of Cardiology, 68(13), 1435. Elsevier USA van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polašek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-1448 . https://doi.org/10.1016/j.jacc.2016.07.729 Journal of the American College of Cardiology 68 (2016): 1435–1448. doi:10.1016/j.jacc.2016.07.729 info:cnr-pdr/source/autori:van der Harst, Pim; van Setten, Jessica; Verweij, Niek; Vogler, Georg; Franke, Lude; Maurano, Matthew T.; Wang, Xinchen; Leach, Irene Mateo; Eijgelsheim, Mark; Sotoodehnia, Nona; Hayward, Caroline; Sorice, Rossella; Meirelles, Osorio; Lyytikainen, Leo-Pekka; Polasek, Ozren; Tanaka, Toshiko; Arking, Dan E.; Ulivi, Sheila; Trompet, Stella; Mueller-Nurasyid, Martina; Smith, Albert V.; Doerr, Marcus; Kerr, Kathleen F.; Magnani, Jared W.; Del Greco, Fabiola; Zhang, Weihua; Nolte, Ilja M.; Silva, Claudia T.; Padmanabhan, Sandosh; Tragante, Vinicius; Esko, Tonu; Abecasis, Gonclo R.; Adriaens, Michiel E.; Andersen, Karl; Barnett, Phil; Bis, Joshua C.; Bodmer, Rolf; Buckley, Brendan M.; Campbell, Harry; Cannon, Megan V.; Chakravarti, Aravinda; Chen, Lin Y.; Delitala, Alessandro; Devereux, Richard B.; Doevendans, Pieter A.; Dominiczak, Anna F.; Ferrucci, Luigi; Ford, Ian; Gieger, Christian; Harris, Tamara B.; Haugen, Eric; Heinig, Matthias; Hernandez, Dena G.; Hillege, Hans L.; Hirschhorn, Joel N.; Hofman, Albert; Hubner, Norbert; Hwang, Shih-Jen; Iorio, Annamaria; Kahonen, Mika; Kellis, Manolis; Kolcic, Ivana; Kooner, Ishminder K.; Kooner, Jaspal S.; Kors, Jan A.; Lakatta, Edward G.; Lage, Kasper; Launer, Lenore J.; Levy, Daniel; Lundby, Alicia; Macfarlane, Peter W.; May, Dalit; Meitinger, Thomas; Metspalu, Andres; Nappo, Stefania; Naitza, Silvia; Neph, Shane; Nord, Alex S.; Nutile, Teresa; Okin, Peter M.; Olsen, Jesper V.; Oostra, Ben A.; Penninger, Josef M.; Pennacchio, Len A.; Pers, Tune H.; Perz, Siegfried; Peters, Annette; Pinto, Yigal M.; Pfeufer, Arne; Pilia, Maria Grazia; Pramstaller, Peter P.; Prins, Bram P.; Raitakari, Olli T.; Raychaudhuri, Soumya; Rice, Ken M.; Rossin, Elizabeth J.; Rotter, Jerome I.; Schafer, Sebastian; Schlessinger, David; Schmidt, Carsten O.; Sehmi, Jobanpreet; Sillje, Herman H. W.; Sinagra, Gianfranco; Sinner, Moritz F.; Slowikowski, Kamil; Soliman, Elsayed Z.; Spector, Timothy D.; Spiering, Wilko; Stamatoyannopoulos, John A.; Stolk, Ronald P.; Strauch, Konstantin; Tan, Sian-Tsung; Tarasov, Kirill V.; Trinh, Bosco; Uitterlinden, Andre G.; van den Boogaard, Malou; van Duijn, Cornelia M.; van Gilst, Wiek H.; Viikari, Jorma S.; Visscher, Peter M.; Vitart, Veronique; Voelker, Uwe; Waldenberger, Melanie; Weichenberger, Christian X.; Westra, Harm-Jan; Wijmenga, Cisca; Wolffenbuttel, Bruce H.; Yang, Jian; Bezzina, Connie R.; Munroe, Patricia B.; Snieder, Harold; Wright, Alan F.; Rudan, Igor; Boyer, Laurie A.; Asselbergs, Folkert W.; van Veldhuisen, Dirk J.; Stricker, Bruno H.; Psaty, Bruce M.; Ciullo, Marina; Sanna, Serena; Lehtimaki, Terho; Wilson, James F.; Bandinelli, Stefania; Alonso, Alvaro; Gasparini, Paolo; Jukema, J. Wouter; Kaeaeb, Stefan; Gudnason, Vilmundur; Felix, Stephan B.; Heckbert, Susan R.; de Boer, Rudolf A.; Newton-Cheh, Christopher; Hicks, Andrew A.; Chambers, John C.; Jamshidi, Yalda; Visel, Axel; Christoffels, Vincent M.; Isaacs, Aaron; Samani, Nilesh J.; de Bakker, Paul I. W./titolo:52 Genetic Loci Influencing Myocardial Mass/doi:10.1016%2Fj.jacc.2016.07.729/rivista:Journal of the American College of Cardiology (Print)/anno:2016/pagina_da:1435/pagina_a:1448/intervallo_pagine:1435–1448/volume:68 Journal of the American College of Cardiology, 68(13), 1435-1448 van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polašek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-48 . https://doi.org/10.1016/j.jacc.2016.07.729 Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier USA Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier Inc. Journal of the American College of Cardiology, 68(13), 1435-1448. ELSEVIER SCIENCE INC J. Am. Coll. Cardiol. 68, 1435-1448 (2016) van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polasek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-48 . https://doi.org/10.1016/j.jacc.2016.07.729 Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2016.07.729 |
| Popis: | BACKGROUND Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death.OBJECTIVES This meta-analysis sought to gain insights into the genetic determinants of myocardial mass.METHODS We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment.RESULTS We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p CONCLUSIONS Taken together, our findings provide new insights into genes and biological pathways controlling myocardial mass and may help identify novel therapeutic targets. (C) 2016 by the American College of Cardiology Foundation. |
| Databáze: | OpenAIRE |
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