Anti-inflammatory actions of pentacyclic triterpenes
| Autor: | E.-R. Sailer, Hasan Safayhi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.drug_class
Pharmaceutical Science Sapogenin Pharmacology Biology Anti-inflammatory Analytical Chemistry Proinflammatory cytokine Mediator Drug Discovery medicine Animals Humans Hormone metabolism Folk medicine Plants Medicinal Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Experimental Animal Models Triterpenes Disease Models Animal Complementary and alternative medicine Molecular Medicine Pentacyclic Triterpenes Inflammation Mediators Signal Transduction |
| Zdroj: | Planta medica. 63(6) |
| ISSN: | 0032-0943 |
| Popis: | Pentacyclic triterpenes (PTs) as aglycones of saponins have a wide distribution in plants, and many of them have been used as anti-inflammatory remedies in folk medicine. This survey critically reviews the effects of PTs on proinflammatory mediator signalling pathways and data from experimental animal models and clinical trials. Because the knowledge of their actions is far from being satisfactory a critical summary of the partly promising but mostly scattered and preliminary data might promote productive research on chances and risks of PTs. Antiproliferative and anti-infectious actions and effects on intracellular cell signalling and hormone metabolism are beyond the scope of this short review, although such effects might also contribute to the understanding of the systemic anti-inflammatory actions of aglycones. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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