Effects of Motilin and Mitemcinal (GM-611) on Gastrointestinal Contractile Activity in Rhesus Monkeys In Vivo and In Vitro
| Autor: | Kenji Yogo, Satoshi Omura, Zen Itoh, Hisanori Takanashi, Masao Koto, Ken-ichi Ozaki |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Receptors Neuropeptide medicine.medical_specialty Duodenum Physiology Motilin receptor Erythromycin Biology Receptors Gastrointestinal Hormone Motilin chemistry.chemical_compound Gastrointestinal Agents In vivo Internal medicine medicine Animals Mitemcinal Antibacterial agent Myoelectric Complex Migrating Gastrointestinal tract Binding Sites Dose-Response Relationship Drug Gastric emptying Stomach digestive oral and skin physiology Gastroenterology Macaca mulatta Endocrinology chemistry Injections Intravenous Rabbits Gastrointestinal Motility hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Digestive Diseases and Sciences. 52:3112-3122 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | Neither the presence of motilin receptors nor their action has been investigated in monkeys. The object of this study was to determine the effects of motilin and mitemcinal (GM-611), an erythromycin derivative, on the gastrointestinal tract in rhesus monkeys in vivo and in vitro. In in vivo investigations in conscious monkeys, both motilin and mitemcinal induced migrating motor complex-like contractions in the interdigestive state and also accelerated gastric emptying. In in vitro investigations, the presence of motilin receptors in the gastrointestinal tract was demonstrated by receptor binding assays. Motilin and mitemcinal contracted isolated duodenum strips in a concentration-dependent manner. In conclusion, rhesus monkeys may be useful for studying the physiological and pharmacological roles of the motilin agonistic mechanism because they show reactivity to motilin both in vivo and in vitro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink