Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway
| Autor: | He-fei Zhang, Yuan-yuan Yao, Bai-bing Zhang, Koichi Kawakami, Jiulin Du |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Central Nervous System Light Sensory system Retinal ganglion Animals Genetically Modified 03 medical and health sciences Limbic system Thalamus Basal ganglia medicine Animals Visual Pathways Zebrafish Body Patterning Neurons Thigmotaxis biology Behavior Animal General Neuroscience Zebrafish Proteins biology.organism_classification 030104 developmental biology medicine.anatomical_structure Habenula Retinal ganglion cell Larva Psychology Neuroscience |
| Zdroj: | Neuron. 93(4) |
| ISSN: | 1097-4199 |
| Popis: | Habenula (Hb) plays critical roles in emotion-related behaviors through integrating inputs mainly from the limbic system and basal ganglia. However, Hb also receives inputs from multiple sensory modalities. The function and underlying neural circuit of Hb sensory inputs remain unknown. Using larval zebrafish, we found that left dorsal Hb (dHb, a homolog of mammalian medial Hb) mediates light-preference behavior by receiving visual inputs from a specific subset of retinal ganglion cells (RGCs) through eminentia thalami (EmT). Loss- and gain-of-function manipulations showed that left, but not right, dHb activities, which encode environmental illuminance, are necessary and sufficient for light-preference behavior. At circuit level, left dHb neurons receive excitatory monosynaptic inputs from bilateral EmT, and EmT neurons are contacted mainly by sustained ON-type RGCs at the arborization field 4 of retinorecipient brain areas. Our findings discover a previously unidentified asymmetrical visual pathway to left Hb and its function in mediating light-preference behavior. VIDEO ABSTRACT. |
| Databáze: | OpenAIRE |
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