Theophylline increases saliva sonic hedgehog and improves taste dysfunction
| Autor: | Alexandra B. Knöppel, Mona Abdelmeguid, Robert I. Henkin, William A. Stateman, Suzanna Hosein |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Taste medicine.medical_specialty Saliva animal structures Adolescent Phosphodiesterase Inhibitors Enzyme-Linked Immunosorbent Assay 03 medical and health sciences Taste Disorders 0302 clinical medicine stomatognathic system Theophylline Internal medicine Taste bud medicine Humans Hedgehog Proteins Sonic hedgehog 030223 otorhinolaryngology Receptor Child General Dentistry Aged Aged 80 and over biology business.industry Hypogeusia Cell Biology General Medicine Middle Aged stomatognathic diseases Endocrinology medicine.anatomical_structure Treatment Outcome Otorhinolaryngology embryonic structures biology.protein Taste function Female medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Archives of oral biology. 82 |
| ISSN: | 1879-1506 |
| Popis: | Objective To determine changes in saliva sonic hedgehog (Shh) and in taste dysfunction before and after oral theophylline treatment. Design Shh was measured in parotid saliva of both normal subjects and patients with taste dysfunction of multiple etiologies by use of a sensitive spectrophotometric ELISA assay. Taste dysfunction was defined clinically by both subjective inhibition of taste function (including acuity loss) and impaired gustometry. Results Theophylline treatment increased patient saliva Shh and improved taste dysfunction both subjectively and by gustometry. Conclusions By use of these systematic clinical measurements theophylline can be demonstrated to increase saliva Shh and improve taste dysfunction. These results are consistent with saliva Shh acting as a taste bud growth factor which stimulates stem cells of taste buds to initiate development and perpetuation of taste bud receptors. Measurements of saliva Shh provide an important marker for the presence of taste dysfunction and in the improvement by theophylline treatment. |
| Databáze: | OpenAIRE |
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