Binding behaviour of antibodies reacting specifically with an immunodominant region of the transmembrane protein gp41 of HIV-1
| Autor: | Tomas Porstmann, Peter Pas, Sven-Holger Döpel, Rüdiger von Baehr, Peter Henklein, Roland Grunow |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.drug_class
Molecular Sequence Data Blood Donors Immunodominance HIV Antibodies Gp41 Monoclonal antibody Peptide Mapping Epitope Epitopes Antigen Virology medicine Humans Amino Acid Sequence Peptide sequence Binding Sites biology Antibodies Monoclonal virus diseases Molecular biology HIV Envelope Protein gp41 Polyclonal antibodies HIV-1 biology.protein Antibody |
| Zdroj: | Journal of Virological Methods. 28:189-198 |
| ISSN: | 0166-0934 |
| DOI: | 10.1016/0166-0934(90)90034-d |
| Popis: | A highly conserved region of the transmembrane protein gp41 of the HIV-1 was found in which the amino acid sequence 606 to 620 was characterized as an immunodominant region. The binding behaviours of a human monoclonal antibody and of polyclonal specific antibodies in sera of HIV-infected persons to this particular sequence have been studied. In two sandwich-type ELISAs with synthetic peptides as antigen representing this region, sera of 312 HIV-infected persons at all stages could be clearly discriminated against 500 anti-HIV antibody negative sera of healthy blood donors. |
| Databáze: | OpenAIRE |
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