Evidence for Unimpaired Pancreatic Secretion and Hepatic Removal of Insulin in Healthy Offspring of Type 2 (Noninsulin-Dependent) Diabetic Couples
| Autor: | Ivana Zavaroni, A. Pezzarossa, O. Alpi, Ugo Butturini, Enzo Bonora, Carlo Coscelli, F. Bruschi, Elisabetta Dall'Aglio |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Offspring Endocrinology Diabetes and Metabolism medicine.medical_treatment Administration Oral chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus medicine Humans Insulin Secretion Family history Pancreas Glucose tolerance test C-Peptide medicine.diagnostic_test business.industry C-peptide Glucose Tolerance Test medicine.disease medicine.anatomical_structure Diabetes Mellitus Type 2 Liver chemistry Female business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1423-0046 0301-0163 |
| DOI: | 10.1159/000179986 |
| Popis: | The aim of the present study was to investigate the secretion and the hepatic removal of insulin in a group of 14 unaffected offspring of 14 type 2 (noninsulin-dependent) diabetic couples compared to 14 healthy subjects without family history of diabetes mellitus. The two groups, each consisting of 5 obese and 9 nonobese subjects, were carefully matched for sex, age, and body weight. We examined glucose, insulin, and C-peptide levels, as well as C-peptide to insulin ratios and relations during the oral glucose tolerance test. Glucose concentrations and incremental areas were similar in the two groups, as well as insulin and C-peptide levels and areas. C-peptide to insulin molar ratios, both in fasting state and after glucose load, as well as relations between C-peptide and insulin incremental areas were not different. Our results suggest that the healthy offspring of type 2 diabetic couples have a normal response of beta-cell to oral glucose as well as a normal removal of insulin by the liver. |
| Databáze: | OpenAIRE |
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