Activity in mice of recombinant BCG-EgG1Y162 vaccine for Echinococcus granulosus infection
| Autor: | Delixiati Yimiti, Yan Xin, Hao Wen, Chunbao Cao, Hai-Mei Ma, Shanshan Peng, Xiumin Ma, Jianbing Ding, Fengbo Zhang, Hui Zhao, Yuejie Zhu |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Secondary infection T-Lymphocytes 030231 tropical medicine Immunology Antibodies Helminth Enzyme-Linked Immunosorbent Assay Biology Immunoglobulin E Lymphocyte Activation Immunoglobulin G EgG1Y162 03 medical and health sciences 0302 clinical medicine Immune system Echinococcosis vaccine parasitic diseases medicine Immunology and Allergy Animals Echinococcus granulosus Cell Proliferation Pharmacology Mice Inbred BALB C Vaccines Synthetic medicine.disease biology.organism_classification Virology Research Papers Vaccination Disease Models Animal 030104 developmental biology Antigens Helminth biology.protein BCG Vaccine BCG vaccine |
| Zdroj: | Human Vaccines & Immunotherapeutics |
| ISSN: | 2164-554X |
| Popis: | Cystic hydatid disease is a zoonotic parasitic disease caused by Echinococcus granulosus which is distributed worldwide. The disease is difficult to treat with surgery removal is the only cure treatment. In the high endemic areas, vaccination of humans is believed a way to protect communities from the disease. In this study we vaccinated BALB/c mice with rBCG-EgG1Y162, and then detected the level of IgG and IgE specifically against the recombinant protein by ELISA, rBCG-EgG1Y162 induced strong and specific cellular and humoral immune responses. In vitro study showed that rBCG-EgG1Y162 vaccine not only promote splenocytes proliferation but also active T cell. In addition, the rBCG-EgG1Y162 induced a protection in the mice against secondary infection of Echinococcus granulosus. |
| Databáze: | OpenAIRE |
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