Retinoblastoma: Review of Current Management
| Autor: | Richard L. Hurwitz, Sharon E. Plon, Patricia Chévez-Barrios, Murali Chintagumpala, Evelyn A. Paysse |
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| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
Pediatrics medicine.medical_specialty Retinal Neoplasm business.industry Retinoblastoma Retinal Neoplasms medicine.medical_treatment Pediatric Oncologist Disease medicine.disease eye diseases Surgery Radiation therapy Oncology Humans Medicine Genetic Predisposition to Disease Stage (cooking) business Strabismus Radiation oncologist |
| Zdroj: | The Oncologist. 12:1237-1246 |
| ISSN: | 1549-490X 1083-7159 |
| DOI: | 10.1634/theoncologist.12-10-1237 |
| Popis: | The most common ocular cancer in children is retinoblastoma. It affects approximately 300 children in the U.S. every year. It can affect one or both eyes and the disease can be inherited. Altered discoloration of the pupil and strabismus are the usual symptoms that lead to medical attention. Subsequent appropriate diagnostic studies and care provided by a multidisciplinary team, including an ophthalmologist, a pediatric oncologist, a radiation oncologist, and a geneticist, among others, often result in optimal short-term and long-term care. The best initial and subsequent treatments are based on whether the child has unilateral or bilateral disease, the stage of the disease, and the age of the child. Enucleation, chemotherapy, and various forms of radiation therapy along with local ophthalmic therapies can be used in the treatment of retinoblastoma. Cure rates are high in children when the tumor is confined to the eye and has not spread systemically or into the orbit or brain. Children with the heritable form of retinoblastoma are at high risk for developing subsequent malignancies, most commonly sarcomas. This risk is greater for those children with the heritable form of the disease who were exposed to ionizing radiation at age |
| Databáze: | OpenAIRE |
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