Gestational diabetes prevalence and outcomes in women undergoing assisted reproductive techniques (ART)

Autor: Gemma, Sesmilo, Pilar, Prats, Manuel, Álvarez, Irene, Romero, Mireia, Guerrero, Ignacio, Rodríguez, Alberto, Rodríguez-Melcón, Sandra, Garcia, Bernat, Serra Also
Rok vydání: 2022
Předmět:
Zdroj: Endocrinología, Diabetes y Nutrición. 69:837-843
ISSN: 2530-0164
Popis: Infertility affects millions worldwide and use of assisted reproductive techniques (ART) is in high demand.To investigate whether women that underwent ART at our hospital had a higher incidence of GDM than women who conceived spontaneously, if the ART subtype affects the GDM rate and to study obstetrical outcomes in women with GDM in both groups.This was a retrospective analysis of prospectively collected data of singleton pregnancies attended at Hospital Universitari Dexeus between 2008 and 2019. Age18 years, pregestational diabetes, metformin prior to pregnancy and multiple pregnancies were excluded.A total of 29,529 patients were included. Pregnancy was achieved by ART in 2596 (8.8%): in vitro fertilisation (IVF/ICSI) 32.8%, frozen embryo transfer (FET) 37.7%, oocyte donor receptors (ODR) 17.2% and insemination 12.2%. The GDM rate was 8.9% (12.7% in ART vs 8.5% in non-ART, p0.001). The GDM was 11.2% in IVF/ICSI, 17.7% in ODR, 13% in FET and 9.1% in the insemination group (p=0.001). In a multivariable analysis adjusting for age, parity and BMI, ART was not associated with GDM [OR 1.03 (0.90-1.19)], nor was type of ART. Pregnancy outcomes in GDM patients were similar in both groups except for C-section rates (30.0% in ART vs 15.9% in non-ART (p0.001).Despite a higher prevalence of GDM in ART pregnancies, ART was not associated with an increased risk of GDM when adjusting for age, parity and BMI. The prognosis of GDM in ART and non-ART was similar except for C-section rates.
Databáze: OpenAIRE