Synthesis, antimicrobial, and antitumor activity of a series of palladium(II) mixed ligand complexes
| Autor: | Badar Taqui Khan, S. Shamsuddin, K. Najmuddin, J.P. Bhatt, K. Annapoorna |
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| Rok vydání: | 1991 |
| Předmět: |
Magnetic Resonance Spectroscopy
Pyrimidine Cell Survival Stereochemistry Carboxylic acid Proteus vulgaris chemistry.chemical_element Guanosine Antineoplastic Agents CHO Cells Microbial Sensitivity Tests Biochemistry Chemical synthesis Inorganic Chemistry chemistry.chemical_compound Cricetinae Animals Humans chemistry.chemical_classification Bacteria biology Ligand biology.organism_classification Anti-Bacterial Agents Pyrimidines chemistry Epidermoid carcinoma Palladium Bacillus subtilis HeLa Cells |
| Zdroj: | Journal of Inorganic Biochemistry. 44:55-63 |
| ISSN: | 0162-0134 |
| Popis: | Mixed ligand complexes of cisdichloromethioninepalladium(II) with 2-mercaptopyrimidine and 2-aminopyrimidine were synthesized and characterized by elemental analysis, conductivity data, infrared, and 1H NMR and 13C NMR spectra. In these mixed ligand complexes methionine coordinates to palladium through amino nitrogen and sulphur, thus leaving a free carboxylic acid group. The pyrimidine ligand coordinates to metal ion through N3. Mixed ligand complexes of cisdichloroethioninepalladium(II) with cytosine and guanosine were synthesized and characterized earlier. All the above mixed ligand complexes were screened for antimicrobial activity against Vibrio parahaemolyticus, Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli, Shigella flexnerri, Salmonella typhii, Klebsella pneumoniae, and Vibrio cholerae. It was found that complexes [Pd(methy)Cl2]; [Pd(meth)(2merpy)Cl]Cl; [Pd(meth)(2ampy)Cl]Cl; [Pd(ethio)Cl2]; [Pd(ethio)(cyt)Cl]Cl; and [Pd(ethio)(guo)Cl]Cl showed broad spectrum antimicrobial activity against all the human pathogens tested, however [Pd(meth)(2merpy)Cl]Cl eliminated plasmid with 100% frequency. These complexes have also been screened in vitro for antitumor activity against Hela (Epidermoid Carcinoma Cervix) and CHO cell lines. An excellent correlation between the antitumor activity of Pd(II) complexes and their ability to cure plasmids exists. |
| Databáze: | OpenAIRE |
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