Toxicity assessment of zinc sulfate: A commonly used compound
| Autor: | Giray Buğra Akbaba |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Mitotic index Maximum Tolerated Dose Health Toxicology and Mutagenesis Meristem Mitosis chemistry.chemical_element Zinc 010501 environmental sciences Toxicology medicine.disease_cause Plant Roots Risk Assessment 01 natural sciences Chromosome aberration 03 medical and health sciences Occupational Exposure Onions medicine Humans Cytotoxicity 030304 developmental biology 0105 earth and related environmental sciences EC50 Chromosome Aberrations 0303 health sciences Chromatography Cytotoxins Public Health Environmental and Occupational Health Middle Aged Zinc Sulfate Occupational Diseases chemistry Distilled water Toxicity Female Genotoxicity Mutagens |
| Zdroj: | Toxicology and Industrial Health. 36:779-787 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233720944771 |
| Popis: | Because zinc sulfate (ZnSO4) is widely used in many fields such as biomedicine, electronics, and chemistry, it is important to evaluate its toxic effects. In this study, the cyto-genotoxic effects of ZnSO4 on meristematic cells in the root tip of Allium cepa L. were investigated. After calculating the effective concentration (EC50 = 70 ppm) of ZnSO4, A. cepa root tip cells were suspended for 24, 48, 72, and 96 h in solutions of 35 ppm (EC50/2), 70 ppm (EC50), and 140 ppm (EC50 × 2) concentrations. Using the counts of dividing cells, the mitotic index (MI) was calculated. Chromosome aberration index (CAI) was determined from percentages of abnormal cells. When the obtained data were statistically evaluated, it was determined that all application concentrations caused a significant decrease in MI and an increase in CAI compared to the control group (distilled water). It was concluded that increased ZnSO4 dose concentrations and exposure times caused cytotoxicity and genotoxicity in the root cells of A. cepa L. |
| Databáze: | OpenAIRE |
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