Intermediate phenotype analysis of patients, unaffected siblings, and healthy controls identifies VMAT2 as a candidate gene for psychotic disorder and neurocognition
| Autor: | Simons, C.J., van Winkel, R., Bruggeman, R., Cahn, W., de Haan, L., Kahn, R.S., Krabbendam, L., Linzen, D., Myin-Germeys, I., van Os, J, Wiersma, D. |
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| Přispěvatelé: | Adult Psychiatry, Amsterdam Neuroscience, Educational Neuroscience, LEARN! - Social cognition and learning, LEARN! - Brain, learning and development, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Male cognition Psychosis Candidate gene medicine.medical_specialty Genotype Single-nucleotide polymorphism Polymorphism Single Nucleotide Young Adult single nucleotide polymorphism Internal medicine Odds Ratio Medicine Humans Genetic Predisposition to Disease psychosis Allele Alleles Genetic Association Studies siblings Genetics business.industry Case-control study Regular Article medicine.disease vesicular monoamine transporter 2 (VMAT2) schizophrenia Psychiatry and Mental health Phenotype Psychotic Disorders Schizophrenia Case-Control Studies Vesicular Monoamine Transport Proteins Female FKBP5 business Cognition Disorders Neurocognitive |
| Zdroj: | Schizophrenia bulletin, 39(4), 848-856. Oxford University Press Simons, C J, van Winkel, R, Bruggeman, R, Cahn, W, de Haan, L, Kahn, R S, Krabbendam, L, Linzen, D, Myin-Germeys, I, van Os, J & Wiersma, D 2013, ' Intermediate phenotype analysis of patients, unaffected siblings, and healthy controls identifies VMAT2 as a candidate gene for psychotic disorder and neurocognition ', Schizophrenia Bulletin, vol. 39, no. 4, pp. 848-56 . https://doi.org/10.1093/schbul/sbs067 Schizophrenia Bulletin, 39(4), 848-56. Oxford University Press Schizophrenia Bulletin, 39(4), 848-856. Oxford University Press |
| ISSN: | 0586-7614 |
| Popis: | Psychotic disorders are associated with neurocognitive alterations that aggregate in unaffected family members, suggesting that genetic vulnerability to psychotic disorder impacts neurocognition. The aim of the present study was to investigate whether selected schizophrenia candidate single nucleotide polymorphisms (SNPs) are associated with (1) neurocognitive functioning across populations at different genetic risk for psychosis (2) and psychotic disorder. The association between 152 SNPs in 43 candidate genes and a composite measure of neurocognitive functioning was examined in 718 patients with psychotic disorder. Follow-up analyses were carried out in 750 unaffected siblings and 389 healthy comparison subjects. In the patients, 13 associations between SNPs and cognitive functioning were significant at P |
| Databáze: | OpenAIRE |
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