Immunohistochemical expression and localization of cytokines/chemokines/growth factors in gastric cancer
| Autor: | Thangarajan Rajkumar, Uthandaraman Mahalinga Raja, Ayloor Seshadri Ramakrishnan, Gopisetty Gopal, Sundersingh Shirley |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Stromal cell medicine.medical_treatment Immunology IGFBP3 PDGFRB Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms medicine Humans Immunology and Allergy Molecular Biology Aged Tissue microarray Cancer Hematology Middle Aged Prognosis medicine.disease Immunohistochemistry Neoplasm Proteins Gene Expression Regulation Neoplastic CCL20 030104 developmental biology Cytokine 030220 oncology & carcinogenesis Female Chemokines |
| Zdroj: | Cytokine. 89:82-90 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2016.08.032 |
| Popis: | Our previous studies on gastric cancer tissue and patient plasma samples identified several cytokines/chemokines/growth factors to be differentially expressed, compared to normal samples. In this study our aim was to understand the localization patterns of the markers in gastric tissues. We investigated the expression of PDGFRB, CCL3, MMP3, CXCL8, CXCL10, CCL20, IGFBP3, CXCL9, SPP1, CCL18, TIMP1, CCL15, CXCL5 and CCL4 in gastric tissues using Immunohistochemistry (IHC) on Tissue Microarrays (TMA). The TMA comprised of 25 apparently normal (AN), 87 paired normal (PN) and 134 gastric cancer (T) tissues. The epithelial and stromal expression of markers and their correlation with patient characteristics and outcome were analyzed. Several of the markers [PDGFRB (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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