Multifocal alterations of white matter accompany the transition from normal cognition to dementia in Parkinson’s disease patients

Autor: Loukas G. Astrakas, Maria I. Argyropoulou, Maria Chondrogiorgi, V. Xydis, Anastasia K. Zikou, Angelo Antonini, Luca Weis, Spiridon Konitsiotis
Rok vydání: 2018
Předmět:
Male
Parkinson's disease
Neuropsychological Tests
Audiology
Corpus callosum
Tract-based spatial statistics
Behavioral Neuroscience
Cognition
0302 clinical medicine
Nuclear Medicine and Imaging
Medicine
Cingulum (brain)
Neuropsychological assessment
medicine.diagnostic_test
05 social sciences
Parkinson Disease
White Matter
Psychiatry and Mental health
Diffusion Tensor Imaging
medicine.anatomical_structure
Neurology
Disease Progression
Female
Radiology
MRI
medicine.medical_specialty
Cognitive Neuroscience
Parkinson’s disease dementia
050105 experimental psychology
White matter
03 medical and health sciences
Cellular and Molecular Neuroscience
Image Interpretation
Computer-Assisted
Fractional anisotropy
Humans
Dementia
Cognitive Dysfunction
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Aged
business.industry
Axial diffusivity
medicine.disease
Diffusion tensor imaging
Radiology
Nuclear Medicine and Imaging
Neurology (clinical)
Psychiatry and Mental Health
Cross-Sectional Studies
business
030217 neurology & neurosurgery
Diffusion MRI
Zdroj: Brain Imaging and Behavior. 13:232-240
ISSN: 1931-7565
1931-7557
Popis: The purpose of the present study was to investigate the pattern of white matter (WM) changes associated with Parkinson's disease (PD)-related cognitive impairment by using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) measures. Diffusion Tensor Imaging (DTI) was performed in 21 PD-patients with dementia (PDD) and in an age-matched control group including 40 PD-patients without dementia (PD-CTRL). The Parkinson's disease-Cognitive Rating Scale (PD-CRS) was used for patients' neuropsychological assessment. Local microstructural WM differences associated with the presence of cognitive impairment were tested using tract-based spatial statistics analysis. Multiple regression models investigated the association of DTI indices with total PD-CRS score, PD-CRS raw items and other clinical measures across the whole study sample. Significant FA decreases were found in PDD compared to PD-CTRL patients mainly in the body of corpus callosum, corona radiata and cingulum. Lower PD-CRS score was significantly associated with decreased FA, MD and AD values in multiple WM tracts primarily located in prefrontal and limbic areas as well as across the corpus callosum. Lower performance in specific PD-CRS raw items was also associated with FA decreases in major WM tracts. The results suggest that multifocal microstructural changes of WM accompany the transition from normal to demented cognitive state in PD-patients. The corpus callosum, the corona radiata and the cingulum are among the regions mostly affected during this course. A progressive axonal degeneration is proposed as a key underlying mechanism.
Databáze: OpenAIRE
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