Long-term implantation test and tumorigenicity of polyvinyl alcohol hydrogel plates
| Autor: | Yong-Ho Li, Kazuya Matsumoto, Takashi Sekine, Tohru Tsuda, Yasuhiko Shimizu, Suong-Hyu Hyon, Hiroki Ueda, Tatsuo Nakamura, Masatoshi Inoue, Liu Yu, Tetsuya Kiyotani |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pathology Time Factors Materials science Tumor incidence Biocompatibility Carcinogenicity Tests Biomedical Engineering Solid-state Urology Biocompatible Materials Polyvinyl alcohol Biomaterials chemistry.chemical_compound Absorbable Implants medicine Animals Rats Wistar Fibrosarcoma integumentary system Water Hydrogels medicine.disease Rats Microscopy Electron chemistry Polyvinyl Alcohol Microscopy Electron Scanning Polyvinyl alcohol hydrogel Sarcoma Implant Follow-Up Studies |
| Zdroj: | Journal of Biomedical Materials Research. 56:289-296 |
| ISSN: | 1097-4636 0021-9304 |
| Popis: | Two types of flat plates made from a polyvinyl alcohol (PVA) hydrogel with a water content of 80 and 20 (PVA-H80, PVA-H20), 20 × 10 × 1 mm in size, were subcutaneously implanted into each of 50 young, male Wistar rats. As a control, a sham operation was done on another set of 50 rats (Sham Op group). The shape and transparency of the PVA hydrogel were unchanged for up to 24 months. Tumors arose in 14 rats from the PVA-H80 group. In the PVA-H20 group, tumors appeared in 15 rats. The average tumor latency was 598 ± 109 days in the PVA-H80 and 637 ± 94 days in the PVA-H20. There was no difference in tumor incidence between the PVA-H20 and PVA-H80 groups (p < 0.05). In the Sham Op group, no malignant tumors appeared. Histopathologically, the tumors induced by hydrogel plates were malignant tumors resembling fibrosarcoma or malignant fibrous histiocytoma. This indicates that PVA hydrogel implants also induce solid state carcinogenesis at a similarly high rate to medical grade hydrophobic material reported in a previous study. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res 56: 289–296, 2001 |
| Databáze: | OpenAIRE |
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