Distinctive Effects of Carvedilol in the Non-Infarct Zone: Remodelling of the Ligated Rat Heart Linked to Oxidative Stress

Autor: Haochen Wang, X F Zhuang, Chengzeng Yin, Ning Ling Sun
Rok vydání: 2009
Předmět:
Vasodilator Agents
Myocardial Infarction
Electrophoretic Mobility Shift Assay
Pharmacology
medicine.disease_cause
Biochemistry
Antioxidants
Propanolamines
Rats
Sprague-Dawley
Myocardial infarction
Carvedilol
Metoprolol
Reverse Transcriptase Polymerase Chain Reaction
NF-kappa B
Heart
General Medicine
Drug Combinations
Matrix Metalloproteinase 8
medicine.anatomical_structure
Acute Disease
Female
Inflammation Mediators
medicine.drug
medicine.medical_specialty
Bunazosin
Blotting
Western
Carbazoles
Alpha (ethology)
Internal medicine
Matrix Metalloproteinase 13
medicine
Animals
RNA
Messenger
cardiovascular diseases
Ligation
Tissue Inhibitor of Metalloproteinase-1
business.industry
Biochemistry (medical)
Cell Biology
medicine.disease
Rats
Oxidative Stress
Endocrinology
Ventricle
Heart failure
Quinazolines
business
Oxidative stress
Zdroj: Journal of International Medical Research. 37:1354-1364
ISSN: 1473-2300
0300-0605
DOI: 10.1177/147323000903700510
Popis: In this study, an experimental rat ligated heart model was used to observe the effect of treatment with carvedilol, metoprolol and metoprolol plus a highly selective α1-adrenergic blocking agent, bunazosin, after acute myocardial infarction (MI). Compared with an untreated MI group, all drug-treated groups demonstrated attenuation of inflammatory mediators, activation of nuclear factor-κB (NF-κB), and increased levels of mRNA and active protein for the collagenases matrix metallopeptidase (MMP)-8 and MMP-13 in the non-infarct zone of the ventricle, as well as inhibition of the increase of left ventricular end-diastolic pressure. Supplementation of metoprolol with bunazosin did not add greatly to the effects of metoprolol alone. Of the three drug treatments, carvedilol showed a uniquely potent antioxidant activity that may strengthen its capacity to inhibit oxidative stress, the release of inflammatory mediators and activation of NF-κB. This study may help provide a mechanistic explanation for the greater benefits shown by carvedilol compared with metoprolol in treating heart failure.
Databáze: OpenAIRE
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