Intrauterine Repair of Cleft Lip-Like Defects in Lambs with a Novel Microclip
| Autor: | Michele L. Evans, Yon H. Zhu, Kerby C. Oberg, Robert A. Hardesty, Wolff M. Kirsch |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Microsurgery
medicine.medical_specialty Time Factors Cleft Lip medicine.medical_treatment Cicatrix Fetus Suture (anatomy) Hysteroscopes medicine Animals Reduction (orthopedic surgery) Endoscopes Wound Healing Repair time Sheep Sutures Fetal surgery business.industry General Medicine Surgery Otorhinolaryngology Operative time Gestation Female Wound healing business |
| Zdroj: | Journal of Craniofacial Surgery. 6:126-131 |
| ISSN: | 1049-2275 |
| DOI: | 10.1097/00001665-199503000-00009 |
| Popis: | Potential for scarless wound healing in fetal surgeries has aroused interest in fetal repair of malformations such as cleft lip. However, current protocols for fetal surgery have entailed fetal externalization, imparting significant risks for mother and fetus. We have developed a unique silver microclip that rapidly approximates tissue, is nonpenetrating, and is well suited for endoscopic use. Using standardized intrauterine surgical techniques, we compared suture versus microclip in the repair of surgically created cleft-like defects in fetal lambs at 124 days' gestation (term, 145 days). Nine fetal lambs were analyzed with bilateral cleft lips; the right cleft was repaired by microclip, seven of the left clefts were repaired by suture, and the remaining two left clefts were not approximated (controls). Results demonstrated excellent wound healing and smooth lip continuity with minimal scar formation after repair by either microclip or suture. The most striking result, however, was in the comparison on intraoperative repair time; the total time for cleft lip repair by microclip averaged 2.5 minutes in contrast to 9.8 minutes for suture. These data suggest a distinct advantage of the microclip in reduction of operative time. Furthermore, its endoscopic application has the potential for making endoscopic fetal surgery a more viable option. |
| Databáze: | OpenAIRE |
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