Three-dimensional structure of foot-and-mouth disease virus and its biological functions
| Autor: | Hui-Chen Guo, Shi-Chong Han, Shiqi Sun |
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| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular Viral Structural Proteins medicine.medical_specialty New horizons Protein Conformation Virus Assembly animal diseases viruses Viral pathogenesis General Medicine Disease Biology biology.organism_classification Virology Virus Medical microbiology Viral life cycle Foot-and-Mouth Disease Virus Infectious disease (medical specialty) medicine Animals Foot-and-mouth disease virus |
| Zdroj: | Archives of Virology. 160:1-16 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | Foot-and-mouth disease (FMD), an acute, violent, infectious disease of cloven-hoofed animals, remains widespread in most parts of the world. It can lead to a major plague of livestock and an economical catastrophe. Structural studies of FMD virus (FMDV) have greatly contributed to our understanding of the virus life cycle and provided new horizons for the control and eradication of FMDV. To examine host-FMDV interactions and viral pathogenesis from a structural perspective, the structures of viral structural and non-structural proteins are reviewed in the context of their relevance for virus assembly and dissociation, formation of capsid-like particles and virus-receptor complexes, and viral penetration and uncoating. Moreover, possibilities for devising novel antiviral treatments are discussed. |
| Databáze: | OpenAIRE |
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