Effect of age and Blood Pressure on Surrogate Markers of Atherosclerosis in Patients with Type 2 Diabetes Mellitus
| Autor: | Meghana Ulhas Ganu, Sanjay G. Godbole, Sudha Srikant Deo, Namrata Bindurao Kulkarni |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty animal structures endocrine system diseases pulse wave velocity Clinical Biochemistry lcsh:Medicine augmentation index Physiology Section Internal medicine Diabetes mellitus medicine Medical history In patient Pulse wave velocity business.industry lcsh:R nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Anthropometry equipment and supplies medicine.disease Surgery arterial stiffness Blood pressure Arterial stiffness Cardiology business |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 8, Iss 6, Pp BC08-BC11 (2014) |
| ISSN: | 2249-782X |
| DOI: | 10.7860/jcdr/2014/7859.4438 |
| Popis: | Background: Increased arterial stiffness may be an important pathway linking diabetes mellitus to increased cardiovascular risk. Aim: The study was conducted to assess the surrogate markers of arterial stiffness in patients with Type 2 diabetes mellitus (T2DM), and compare with age-matched hypertensive and healthy controls. Also the effect of age and blood pressure on these markers was evaluated. Settings and Design: This cross-sectional study was carried out at a tertiary care hospital in West India. Methods: After a detailed medical history and anthropometric evaluation, all the participants were subjected to measurements of Arterial Stiffness Index (ASI), Pulse Wave Velocity (PWV), and Augmentation Index (AIx) using a non-invasive oscillometric method. The four study groups consisted of patients with T2DM (>5 years) along with hypertension, newly diagnosed patients with T2DM ( 140 mmHg compared to those with systolic BP < 140 mmHg. A very strong correlation between PWV and AIx in patients with T2DM and hypertensive controls was observed. Conclusion: This study reveals that markers of arterial stiffness (PWV, ASI, AIx) were increased significantly in patients with T2DM compared to healthy controls. Age and systolic blood pressure had significant influence on these markers. Thus, oscillometric markers have potential utility in identifying subclinical atherosclerosis in patients with T2DM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|