Circulating microRNAs as Promising Biomarkers in Colorectal Cancer
| Autor: | Óscar Rapado-González, José Iglesias-Canle, Ana Álvarez-Castro, Rafael López-López, Laura Muinelo-Romay, María Mercedes Suárez-Cunqueiro |
|---|---|
| Přispěvatelé: | Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Colorectal cancer colorectal cancer Context (language use) Personalized therapy Review medicine.disease_cause lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Internal medicine microRNA medicine circulating exosomes Liquid biopsy personalized therapy liquid biopsy business.industry Cancer Tumor biomarkers lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Microvesicles Circulating MicroRNA 030104 developmental biology Circulating microRNAs tumor biomarkers 030220 oncology & carcinogenesis circulating microRNAs business Carcinogenesis Circulating exosomes |
| Zdroj: | Cancers, Vol 11, Iss 7, p 898 (2019) Cancers Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers11070898 |
| Popis: | Colorectal cancer (CRC) is one of the most common cancers and a leading cause of cancer-related deaths worldwide. Despite numerous advances in therapeutic approaches, this cancer has a poor prognosis when it is diagnosed at late stages. Therefore, the scientific e ort is nowadays directed towards the development of new non-invasive and dynamic biomarkers to improve the survival expectancy of CRC patients. In this sense, deregulated expression of many miRNAs has been shown to play an important role for CRC carcinogenesis and dissemination. Noticeably, an increasing number of studies highlight that circulating miRNAs, including those traveling inside exosomes or those released by tumor cells into circulation, constitute a promising tool for early detection, prognosis and therapy selection of CRC. Therefore, in this review we focus on the clinical potential of blood circulating miRNAs as emerging biomarkers with high value to improve the clinical management of CRC patients, providing a deep and complete perspective of the realities and challenges to translate these biomarkers to the clinical context This study was supported by the Consellería de Cultura, Educación e Ordenación Universitaria da Xunta de Galicia (Spain), grant number: ED431B2017/029 SI |
| Databáze: | OpenAIRE |
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