Monodisperse micro-shell structured gelatin microparticles for temporary chemoembolization
| Autor: | Jin Woong Kim, Hans M. Wyss, Bohyun Kim, DaBin Yim, Sang Woo Han, Song-Ee Choi, Jong-Ho Kim |
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| Přispěvatelé: | Group Wyss, Microsystems |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Glutaral/chemistry
Gelatin/chemistry Materials science food.ingredient Polymers and Plastics Microfluidics Dispersity Capsules Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Gelatin Biomaterials chemistry.chemical_compound Mice food micromechanics Drug Delivery Systems Materials Chemistry Animals Chemoembolization Therapeutic Photographic emulsion microfluidic devices Cross-Linking Reagents/chemistry Minimally invasive procedures hydrogels Capsules/administration & dosage 3T3 Cells 021001 nanoscience & nanotechnology 0104 chemical sciences Drug Liberation Cross-Linking Reagents chemistry Glutaral Emulsions/chemistry Self-healing hydrogels Emulsions Chemoembolization Chemoembolization Therapeutic/methods Glutaraldehyde Particle size 0210 nano-technology Therapeutic/methods Biomedical engineering |
| Zdroj: | Biomacromolecules, 19(2), 386-391. American Chemical Society |
| ISSN: | 1525-7797 |
| DOI: | 10.1021/acs.biomac.7b01479 |
| Popis: | Embolization is a nonsurgical, minimally invasive procedure that deliberately blocks a blood vessel. Although several embolic particles have been commercialized, their much wider applications have been hampered owing mainly to particle size variation and uncontrollable degradation kinetics. Herein we introduce a microfluidic approach to fabricate highly monodisperse gelatin microparticles (GMPs) with a microshell structure. For this purpose, we fabricate uniform gelatin emulsion precursors using a microfluidic technique and consecutively cross-link them by inbound diffusion of glutaraldehyde from the oil continuous phase to the suspending gelatin precursor droplets. A model micromechanic study, carried out in an artificial blood vessel, demonstrates that the extraordinary degradation kinetics of the GMPs, which stems from the microshell structure, enables controlled rupturing while exhibiting drug release under temporary chemoembolic conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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