Association of polypharmacy with fall-related fractures in older Taiwanese people: age- and gender-specific analyses
| Autor: | Tzeng Ji Chen, Chung Yi Li, Tung Ping Su, Hsueh-Hsing Pan, Kwua-Yun Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Gerontology
Male medicine.medical_specialty Prescription Drugs Population Taiwan Poison control Logistic regression GENERAL MEDICINE (see Internal Medicine) Occupational safety and health Fractures Bone PREVENTIVE MEDICINE Sex Factors GERIATRIC MEDICINE Risk Factors Epidemiology Injury prevention Odds Ratio Medicine Humans education Aged Geriatrics Polypharmacy Aged 80 and over education.field_of_study business.industry Research General Medicine Pharmacology and Therapeutics Hospitalization Logistic Models Case-Control Studies Accidental Falls Female business |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | Objective To elucidate the associations between polypharmacy and age- and gender-specific risks of admission for fall-related fractures. Design Nested case–control study. Setting This analysis was randomly selected from all elderly beneficiaries in 2007–2008, and represents some 30% of the whole older insurers using Taiwan's National Health Insurance Research Database. Participants We identified 5933 cases newly admitted for fall-related fractures during 2007–2008, and 29 665 random controls free from fracture. Primary and secondary outcome measures Polypharmacy was defined as the use of fall-related drugs of four or more categories of medications and prescribed related to fall within a 1-year period. Logistic regression models were employed to estimate the ORs and related 95% CIs. The interaction of polypharmacy with age and sex was assessed separately. Results Compared with those who consumed no category of medication, older people who consumed 1, 2, 3 and ≥4 categories of medications were all at significantly increased odds of developing fall-related fractures, with a significant dose–gradient pattern (β=0.7953; p for trend |
| Databáze: | OpenAIRE |
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