HLA-A*31
| Autor: | Chong Tin Tan, Amy Hui-Ping Khor, Kheng Seang Lim, David Bin-Chia Wu, Ching Ching Ng, Zhenli Kwan, Wooi-Chiang Tan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Pharmacology Young Adult 03 medical and health sciences 0302 clinical medicine Asian People Malaysian population Ethnicity Genetics Humans Medicine General Pharmacology Toxicology and Pharmaceutics Allele Child Molecular Biology Alleles Genetics (clinical) Aged HLA-A Antigens business.industry Malaysia Stevens johnson Carbamazepine Middle Aged medicine.disease Dermatology Toxic epidermal necrolysis HLA-B HLA-A stomatognathic diseases 030104 developmental biology HLA-B Antigens Case-Control Studies Stevens-Johnson Syndrome Molecular Medicine Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pharmacogenetics and Genomics. 27:275-278 |
| ISSN: | 1744-6872 |
| Popis: | The majority of the carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis CBZ-SJS/TEN are associated with HLA-B*15:02 in Asian populations where this allele is common. In contrast, the association with HLA-A*31:01 is only reported in Japanese and Europeans. This study aimed to further investigate the association with HLA-A*31:01 besides HLA-B*15:02 in a multiethnic Malaysian population. Twenty-eight CBZ-SJS/TEN cases and 227 CBZ-tolerant controls were recruited. Association was tested by comparing carrier frequencies of the alleles between cases and controls. Significant associations were detected between HLA-B*15:02 and CBZ-SJS/TEN in independent ethnic groups: Malays [P=2.00×10; odds ratio (OR): 49.0; 95% confidence interval (CI): 9.36-256.81], Chinese (P=0.0047; OR: 14.3; 95% CI: 2.38-86.03) and Indians (P=0.04; OR: 13.8; 95% CI: 1.51-124.99). Combined analysis of all ethnic groups showed a significant association with OR Cochran-Mantel-Haenszel (ORCMH) of 26.6 (95% CI: 12.80-55.25; PCMH=2.31×10). In Indians, HLA-A*31:01 was found to be associated significantly with CBZ-SJS/TEN (P=0.023; OR: 10.4; 95% CI: 1.64-65.79) and combined analyses of both variants, HLA-A*31:01 and HLA-B*15:02, increased the strength of the association (P=0.0068; OR: 14.3; 95% CI: 2.20-92.9). Besides HLA-B*15:02, our study found a new association between HLA-A*31:01 and CBZ-SJS/TEN in Indians. |
| Databáze: | OpenAIRE |
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