Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome:A MAGNIMS Study

Autor: Serena Ruggieri, Jelena Drulovic, Stig P. Cramer, Jette L. Frederiksen, Massimo Filippi, Alex Rovira, Alessandro Meani, Frederik Barkhof, Enrico Fainardi, Maria Pia Amato, Gloria Dalla Costa, E. M. M. Strijbis, Maria A. Rocca, Vittorio Martinelli, Wallace J Brownlee, Christian Enzinger, Paolo Preziosa, Giancarlo Comi, Olga Ciccarelli, Xavier Montalban, Claudio Gasperini, Michael Khalil, Sarlota Mesaros, Jovana Ivanovic, Mar Tintoré, KA Miszkiel
Přispěvatelé: Filippi, Massimo, Preziosa, Paolo, Meani, Alessandro, Costa, Gloria Dalla, Mesaros, Sarlota, Drulovic, Jelena, Ivanovic, Jovana, Rovira, Alex, Tintorè, Mar, Montalban, Xavier, Ciccarelli, Olga, Brownlee, Wallace, Miszkiel, Katherine, Enzinger, Christian, Khalil, Michael, Barkhof, Frederik, Strijbis, Eva M M, Frederiksen, Jette L, Cramer, Stig P, Fainardi, Enrico, Amato, Maria Pia, Gasperini, Claudio, Ruggieri, Serena, Martinelli, Vittorio, Comi, Giancarlo, Rocca, Maria A, MAGNIMS Study, Group, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neuroinfection & -inflammation, Neurology
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: MAGNIMS Study Group 2022, ' Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome : A MAGNIMS Study ', Neurology, vol. 98, no. 1, pp. e1-e14 . https://doi.org/10.1212/WNL.0000000000013016
MAGNIMS Study Grp 2022, ' Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome : A MAGNIMS Study ', Neurology, vol. 98, no. 1, pp. E1-E14 . https://doi.org/10.1212/WNL.0000000000013016
Neurology, 98(1), e1-e14. Lippincott Williams and Wilkins
ISSN: 0028-3878
DOI: 10.1212/WNL.0000000000013016
Popis: Background and ObjectivesTo compare the performance of the 2017 revisions to the McDonald criteria with the 2010 McDonald criteria in establishing multiple sclerosis (MS) diagnosis and predicting prognosis in patients with clinically isolated syndrome (CIS) suggestive of MS.MethodsCSF examination and brain and spinal cord MRI obtained ≤5 months from CIS onset and a follow-up brain MRI acquired within 15 months from CIS onset were evaluated in 785 patients with CIS from 9 European centers. Date of second clinical attack and of reaching Expanded Disability Status Scale score (EDSS) ≥3.0, if they occurred, were also collected. Performance of the 2017 and 2010 McDonald criteria for dissemination in space (DIS), dissemination in time (DIT) (including oligoclonal bands assessment), and DIS plus DIT for predicting a second clinical attack (clinically definite MS [CDMS]) and EDSS ≥3.0 at follow-up was evaluated. Time to MS diagnosis for the different criteria was also estimated.ResultsAt follow-up (median 69.1 months), 406/785 patients with CIS developed CDMS. At 36 months, the 2017 DIS plus DIT criteria had higher sensitivity (0.83 vs 0.66), lower specificity (0.39 vs 0.60), and similar area under the curve values (0.61 vs 0.63). Median time to MS diagnosis was shorter with the 2017 vs the 2010 or CDMS criteria (2017 revision, 3.2; 2010 revision, 13.0; CDMS, 58.5 months). The 2 sets of criteria similarly predicted EDSS ≥3.0 milestone. Three periventricular lesions improved specificity in patients ≥45 years.DiscussionThe 2017 McDonald criteria showed higher sensitivity, lower specificity, and similar accuracy in predicting CDMS compared to 2010 McDonald criteria, while shortening time to diagnosis of MS.Classification of EvidenceThis study provides Class II evidence that the 2017 McDonald Criteria more accurately distinguish CDMS in patients early after a CIS when compared to the 2010 McDonald criteria.
Databáze: OpenAIRE
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