Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands
Autor: | Yolande C.A. Keulemans, Mirjam M. Heinen, Bas A.J. Verhage, Leo J. Schouten, P A van den Brandt, P Eijgenraam |
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Přispěvatelé: | Biochemie, Epidemiologie, RS: CARIM School for Cardiovascular Diseases, RS: GROW - School for Oncology and Reproduction |
Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
Male
Cancer Research medicine.medical_specialty hypertension Epidemiology pancreatic cancer Comorbidity Cohort Studies Risk Factors Internal medicine Pancreatic cancer Diabetes mellitus medicine Humans hepatitis Prospective Studies Prospective cohort study diabetes mellitus type II Aged Netherlands Hepatitis business.industry Incidence (epidemiology) Hazard ratio Middle Aged medicine.disease Confidence interval Surgery Pancreatic Neoplasms Oncology Diabetes Mellitus Type 2 Female business Cohort study Follow-Up Studies |
Zdroj: | British Journal of Cancer British Journal of Cancer, 109(11), 2924-2932. Nature Publishing Group |
ISSN: | 1532-1827 0007-0920 |
Popis: | Background: To date, only a few risk factors for pancreatic cancer have been established. We examined prospectively relations between several medical conditions and pancreatic cancer incidence. Methods: In 1986, 120 852 participants completed a baseline questionnaire on cancer risk factors, including several self-reported physician diagnosed medical conditions. At baseline, a random subcohort of 5000 participants was selected using a case-cohort approach for analysis. After 16.3 years of follow-up, 448 pancreatic cancer cases (63% microscopically confirmed) were available for analysis. Results: Diabetes mellitus type II and hepatitis were positively associated with pancreatic cancer risk (multivariable-adjusted hazard ratio: 1.79; 95% confidence interval: 1.12-2.87 and hazard ratio: 1.37; 95% confidence interval: 1.04-1.81, respectively). Furthermore, a positive trend in risk with increasing years of diagnosis of diabetes (P = 0.004) and of hepatitis (P = 0.02) was observed. However, an inverse association was observed between hypertension and pancreatic cancer risk, this was found among microscopically confirmed cases only (hazard ratio: 0.66; 95% confidence interval: 0.49-0.90), while years since diagnosis of hypertension significantly decreased cancer risk (P for trend 0.02). Conclusion: In this prospective study, a positive association was observed between self-reported physician diagnosed diabetes mellitus type II and hepatitis and pancreatic cancer risk, whereas an inverse association was observed with hypertension. |
Databáze: | OpenAIRE |
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