International Normalized Ratio Stability in Warfarin-Experienced Patients with Nonvalvular Atrial Fibrillation
Autor: | Sunita Desai, Winnie W. Nelson, Larry E. Fields, Lang Lu, Jeffery R. Schein, C.V. Damaraju, Peter Wildgoose |
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Jazyk: | angličtina |
Předmět: |
Adult
Male medicine.medical_specialty endocrine system Adolescent Warfarin therapy Young Adult Sex Factors Pharmacotherapy Internal medicine health services administration Atrial Fibrillation medicine Humans In patient heterocyclic compounds Pharmacology (medical) International Normalized Ratio Original Research Article cardiovascular diseases Stroke Aged Retrospective Studies business.industry fungi Warfarin Anticoagulants Atrial fibrillation Retrospective cohort study General Medicine Middle Aged medicine.disease Logistic Models Stroke prevention Anesthesia Cardiology Female business Cardiology and Cardiovascular Medicine Follow-Up Studies medicine.drug |
Zdroj: | American Journal of Cardiovascular Drugs |
ISSN: | 1175-3277 |
DOI: | 10.1007/s40256-015-0120-9 |
Popis: | Background Maintaining stable levels of anticoagulation using warfarin therapy is challenging. Few studies have examined the stability of the international normalized ratio (INR) in patients with nonvalvular atrial fibrillation (NVAF) who have had ≥6 months’ exposure to warfarin anticoagulation for stroke prevention. Objective Our objective was to describe INR control in NVAF patients who had been receiving warfarin for at least 6 months. Methods Using retrospective patient data from the CoagClinic™ database, we analyzed data from NVAF patients treated with warfarin to assess the quality of INR control and possible predictors of poor INR control. Time within, above, and below the recommended INR range (2.0–3.0) was calculated for patients who had received warfarin for ≥6 months and had three or more INR values. The analysis also assessed INR patterns and resource utilization of patients with an INR >4.0. Logistic regression models were used to determine factors associated with poor INR control. Results Patients (n = 9433) had an average of 1.6 measurements per 30 days. Mean follow-up time was 544 days. Approximately 39 % of INR values were out of range, with 23 % of INR values being 3.0. Mean percent time with INR in therapeutic range was 67 %; INR 3.0 was 14 %. Patients with more than one reading of INR >4.0 (~39 %) required an average of one more visit and took 3 weeks to return to an in-range INR. Male sex and age >75 years were predictive of better INR control, whereas a history of heart failure or diabetes were predictive of out-of-range INR values. However, patient characteristics did not predict the likelihood of INR >4.0. Conclusions Out-of-range INR values remain frequent in patients with NVAF treated with warfarin. Exposure to high INR values was common, resulting in increased resource utilization. |
Databáze: | OpenAIRE |
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