| Autor: |
Anton O. Vorvul, Igor I. Bobyntsev, Olga A. Medvedeva, Alexandra Y. Mukhina, Maria V. Svishcheva, Iuliia E. Azarova, Lyudmila A. Andreeva, Nikolay F. Myasoedov |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Neuropeptides. 93:102247 |
| ISSN: |
0143-4179 |
| DOI: |
10.1016/j.npep.2022.102247 |
| Popis: |
The effects of the peptide ACTH(6-9)-Pro-Gly-Pro at doses of 5; 50; 500 μg/kg on the Wistar rats' behaviour and gut mucosal microbiota composition under conditions of chronic immobilization stress (CRS) were studied. CRS increased anxiety-like and depressive-like behaviour, disturbances in locomotor activity and gut dysbiosis. Administration of ACTH(6-9)-Pro-Gly-Pro showed many phenotypic results. Peptide demonstrated anti-depressant activity at doses of 5 and 500 μg/kg by a decrease in the total immobile time in the FST. ACTH(6-9)-Pro-Gly-Pro administered at a dose of 50 μg/kg resulted in an anxiolytic effect which is shown by an increase in the time in the open arms of EPM (p 0.05) and a decrease in the time in the closed arms (p 0.05). Moreover, the peptide led to a decrease in alpha- and beta-diversity of the gut microbiota (p 0.01). Correlation and linear regression analysis demonstrated central mechanisms of ACTH(6-9)-Pro-Gly-Pro anxiolytic activity and both central and peripheral ones in an anti-depressant effect. In this way, peptide ACTH(6-9)-Pro-Gly-Pro could prevent the development of behavioural disturbances and gut dysbiosis caused by chronic restraint stress. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect