Infiltration of thyroid papillary cancer tissue with myeloid leukemic cells: a case report
Autor: | Emre Gezer, Çiğdem Vural, Mehmet Sözen, Umay Kiraz, Alev Selek, Damla Köksalan, Berrin Çetinarslan, Zeynep Cantürk |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Adult Pathology medicine.medical_specialty Myeloid RD1-811 CD34 Case Report Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine Myeloid sarcoma Humans Myeloid Cells Breast Thyroid Neoplasms Thyroid cancer RC254-282 Thyroid biology business.industry CD117 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Myeloid leukemia medicine.disease Prognosis 030104 developmental biology medicine.anatomical_structure Oncology Thyroid Cancer Papillary 030220 oncology & carcinogenesis Papillary thyroid carcinoma biology.protein Surgery Female business |
Zdroj: | World Journal of Surgical Oncology World Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-7 (2021) |
ISSN: | 1477-7819 |
Popis: | Background Extramedullary leukemia, also known as myeloid sarcoma, is a rare form of acute myeloid leukemia and often accompanies bone marrow involvement. Myeloid infiltration of the thyroid gland is extremely rare. Here, a unique case in which thyroid cancer tissue was infiltrated with myeloid cells is presented. Case presentation We present a case of thyroid papillary cancer infiltrated by blastic cells and bilateral breast and axillary myeloid sarcoma in a 30-year-old Caucasian female patient with a history of osteosarcoma and MDS-RAEB2. The patient firstly received 6 cycles of chemotherapy for osteosarcoma, and allogeneic hematopoietic stem cell transplantation was performed after anthracycline-based chemotherapy due to MDS-RAEB2. The patient remained in remission on follow-up in terms of both osteosarcoma and MDS-RAEB2. Malignant features (Bethesda VI) were observed in the fine needle aspiration biopsy performed from a newly developed firm, fixed thyroid nodule approximately 4–5 cm in length in the left thyroid lobe. Because of the Bethesda VI thyroid nodule, the patient underwent total thyroidectomy. In the pathological evaluation, CD34-, CD117-, MPO-, and HLA-DR-positive blastic cells which infiltrated into follicular variant papillary thyroid carcinoma were detected. In the evaluation performed due to blastic cell infiltration, multiple lesions showing increased 18-fluorodeoxyglucose activity in bilateral breast and axillae were detected. Myeloid sarcoma was found as a result of tru-cut biopsy from these lesions. A fungal cystic lesion was detected in the frontal region of the patient who developed altered consciousness after the second cycle of treatment of myeloid sarcoma. During her follow-up in the intensive care unit, she died of cranial septic embolism and acute infarction. Conclusions Here, we present a very interesting case that is the first. A staged approach to diagnosis with methods including immunohistochemical staining, radiological imaging methods, and cytogenetic and molecular analyses can help make the definitive diagnosis. |
Databáze: | OpenAIRE |
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