Analyses of exhaled breath condensate cytokines for identification of lung cancer
| Autor: | Joerg Lehmann, Stephan Fricke, Peter Ruschpler, Christian Gessner, Adrian Gillissen, Ulrich Sack, G. Hoheisel |
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| Přispěvatelé: | Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
exhaled breath condensate
Pathology medicine.medical_specialty business.industry Biochemistry (medical) Clinical Biochemistry bead array medicine.disease respiratory tract diseases 03 medical and health sciences Medical Laboratory Technology angiogenesis lung cancer 0302 clinical medicine 030228 respiratory system 030220 oncology & carcinogenesis cytokine Medicine Identification (biology) Exhaled breath condensate Bead array business Lung cancer |
| Popis: | Early non-invasive detection of lung cancer is a precondition for enabling better prognosis supported by new innovative therapy regimes. The aim of our study was to evaluate angiogenic and inflammatory proteins in exhaled breath condensate (EBC) as markers for lung cancer. Our report presents a diagnostic study of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and tumor necrosis factor-α (TNF-α) in EBC of 300 individuals, 84 patients with lung cancer, 111 patients with stable chronic obstructive pulmonary disease (COPD), and in 105 healthy controls. Detection of VEGF and bFGF in EBC was applicable to discriminate cancer patients from COPD patients as well as from healthy volunteers. Especially VEGF seems to be suitable to discriminate between non-small cell lung cancer (NSCLC) patients and control groups with highest VEGF values in EBC of patients with progressive NSCLC. The concentration of angiogenic factors correlated with disease progression as well as higher tumor stage. This study supports cytokine analysis in EBC as a suitable noninvasive diagnostic screening method for lung cancer detection and monitoring. |
| Databáze: | OpenAIRE |
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