Curcumin Containing PEGylated Solid Lipid Nanoparticles for Systemic Administration: A Preliminary Study
| Autor: | Carmelo Puglia, Agata Campisi, Edy Angela Siciliano, Francesco Castelli, Annamaria Panico, Debora Santonocito, Claudia Carbone, Giovanni Sposito, Maria Grazia Sarpietro |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oxygen radical absorbance capacity
Pharmaceutical Science SLN 02 engineering and technology 030226 pharmacology & pharmacy Micelle Antioxidants Article Analytical Chemistry Polyethylene Glycols lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine lcsh:Organic chemistry cryoprotector Drug Discovery Solid lipid nanoparticle PEG ratio Zeta potential Humans curcumin stealth system Physical and Theoretical Chemistry Turbiscan Cells Cultured Dental Pulp Cell Proliferation Drug Carriers Chromatography Chemistry Stem Cells Organic Chemistry Anti-Inflammatory Agents Non-Steroidal PEGylation 021001 nanoscience & nanotechnology Lipids Chemistry (miscellaneous) Lipophilicity TEM Molecular Medicine Nanoparticles ORAC Nanocarriers 0210 nano-technology |
| Zdroj: | Molecules Volume 25 Issue 13 Molecules, Vol 25, Iss 2991, p 2991 (2020) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25132991 |
| Popis: | Curcumin (CUR) has a wide range of pharmacological properties, including anti-inflammatory and antioxidant activities, and it can be considered a good candidate for the potential treatment of central nervous system (CNS) pathologies, although its use in clinical practice is compromised due to its high lipophilicity. Solid lipid nanoparticles (SLNs) are well-known nanocarriers representing a consolidated approach for the delivery of lipophilic compounds, but their systemic use is limited due their short half-life. The formulation of stealth SLNs (pSLNs) could be a valid strategy to overcome this limit. Curcumin-loaded-pSLNs were prepared by the solvent evaporation method. Formulation was characterized for their mean size, zeta potential, size distribution, and morphology. Drug antioxidant activity was evaluated by Oxygen Radical Absorbance Capacity (ORAC) assay. Finally, the obtained formulations were analyzed in terms of long-term stability. Curcumin-loaded-pSLNs showed good technological parameters with a mean particle size below 200 nm, as confirmed by TEM images, and a zeta potential value around &ndash 30 mV, predicting good long-term stability. Differential Scanning Calorimetry (DSC) analysis confirmed that PEG micelles interacted with the SLN surface this suggests the location of the PEG on the pSLN surface. Therefore, these preliminary studies suggest that the produced formulation could be regarded as a promising carrier for the systemic administration. |
| Databáze: | OpenAIRE |
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