Severe inflammatory ileitis resulting in ileal perforation in association with combination immune checkpoint blockade for metastatic malignant melanoma
| Autor: | Cathy J. Richards, Ali Abdulnabi Mohamed, Kirsten Boyle, Guy Faust |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Ileal Perforation Images In… medicine.medical_treatment Antineoplastic Agents Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Ileitis Colitis Adverse effect Melanoma Chemotherapy Vulvar Neoplasms business.industry General Medicine Middle Aged medicine.disease Ipilimumab Immune checkpoint Blockade 030104 developmental biology Treatment Outcome Intestinal Perforation 030220 oncology & carcinogenesis Drug Therapy Combination Female Skin cancer business |
| Popis: | Immune checkpoint inhibitors have become standard of care in metastatic malignant melanoma management. Despite superior effectiveness to chemotherapy, significant immune-related adverse events (irAE) may occur, particularly if used in combination. Gastrointestinal irAEs were reported with different patterns of involvement. Here, we report the case of a patient who had ileal perforation as a complication of terminal ileitis, without colitis, induced by combination immune checkpoint blockade. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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