Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice
| Autor: | Naoji Amano, Takashi Ogawa, Nobuhiro Sugiyama, Mie Nakamura, Morimichi Hayashi, Hideki Ohnota, Makoto Moro, Hiroyasu Murasawa, Kazuhiro Hongo, Shigeru Yonekubo, Akiko Pawlak, Shinsuke Washizuka, Daimei Sasayama |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Selective Estrogen Receptor Modulators
0301 basic medicine medicine.medical_specialty Ovariectomy Science Ligands Weight Gain Article Mice 03 medical and health sciences 0302 clinical medicine Internal medicine Animals Estrogen Receptor beta Medicine Obesity Receptor Estrogen receptor beta Multidisciplinary Estradiol Molecular Structure Depression business.industry Uterus Organ Size medicine.disease Postmenopause Menopause Disease Models Animal 030104 developmental biology Endocrinology Selective estrogen receptor modulator Ovariectomized rat Female medicine.symptom business Weight gain 030217 neurology & neurosurgery Behavioural despair test Hormone |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-04946-5 |
| Popis: | Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ERβ activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor β-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17β-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERβ in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ERβ-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|