Reconstitution of regulatory T-cell subsets after allogeneic hematopoietic SCT
| Autor: | Patricia Ribaud, Marie Robin, R. Peffault de Latour, Antoine Toubert, Aliénor Xhaard, Guitta Maki, Marc Busson, V-D Kheav, Sarah Abbes, Hélène Moins-Teisserenc, Nathalie Dhedin, Gérard Socié, Maryvonnick Carmagnat |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Time Factors Adolescent Regulatory T cell medicine.medical_treatment Graft vs Host Disease chemical and pharmacologic phenomena Hematopoietic stem cell transplantation T-Lymphocytes Regulatory Flow cytometry medicine Humans Prospective Studies Child Prospective cohort study Aged Transplantation medicine.diagnostic_test business.industry Hematopoietic Stem Cell Transplantation hemic and immune systems Recovery of Function Hematology Middle Aged Allografts medicine.disease Haematopoiesis surgical procedures operative Graft-versus-host disease medicine.anatomical_structure Hematologic Neoplasms Immunology Stem cell business Immunologic Memory |
| Zdroj: | Bone Marrow Transplantation. 49:1089-1092 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/bmt.2014.105 |
| Popis: | Previous studies on regulatory T-cell (Treg) reconstitution after allogeneic hematopoietic SCT (HSCT) have suggested that, within the GVHD process, imbalance between effector T cells and Tregs may be more important than the absolute numbers of circulating Tregs. No study has analyzed naive vs memory Treg reconstitution in a longitudinal cohort with large numbers of patients. The reconstitution of total and subsets of Treg was prospectively analyzed by flow cytometry in 185 consecutive recipients at 3, 6, 12 and 24 months after allogeneic HSCT. The levels of total, naive and memory Tregs increased, mainly within the memory subset, but remained lower than healthy controls up to 2 years after transplantation. Reduced-intensity conditioning and peripheral blood (PBSC) as the source of stem cells were associated with better 3-month reconstitution. In multivariate analysis, PBSC, recipient age ⩽25 and no anti-thymoglobulin in the conditioning regimen were associated with a better Treg reconstitution. Naive Treg long-term reconstitution was mainly influenced by recipient age. Whereas prior acute GVHD impaired Treg reconstitution, Treg subsets (absolute numbers and frequencies relative to CD4(+) T-cell subsets) at 3, 6 and 12 months after HSCT were not associated with the occurrence of a later episode of chronic GVHD. |
| Databáze: | OpenAIRE |
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