Measurement of Neuropsychiatric Symptoms in Clinical Trials Targeting Alzheimer's Disease and Related Disorders
Autor: | Philippe Robert, Renaud David, Emmanuel Mulin, Patrick Mallea |
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Rok vydání: | 2010 |
Předmět: |
medicine.medical_specialty
Alternative medicine lcsh:Medicine lcsh:RS1-441 Pharmaceutical Science Disease Article lcsh:Pharmacy and materia medica assessment tools Drug Discovery medicine Dementia Disease process Psychiatry clinical trials business.industry lcsh:R Cognition Actigraphy medicine.disease Clinical trial Assessment methods Molecular Medicine neuropsychiatric symptoms business Alzheimer’s disease actigraphy |
Zdroj: | Pharmaceuticals Volume 3 Issue 8 Pages: 2387-2397 Pharmaceuticals, Vol 3, Iss 8, Pp 2387-2397 (2010) |
ISSN: | 1424-8247 |
DOI: | 10.3390/ph3082387 |
Popis: | Behavioral and psychological symptoms (BPSD) are now known to be frequently associated to cognitive and functional decline in Alzheimer‘s disease and related disorders. They are present since the early stages of the disease and have negative impact on the disease process. BPSD assessment is crucial in clinical practice and also in future clinical trials targeting disease-modifying therapies for dementia. In this article, we will first review current assessment tools for BPSD, mainly global and domain-specific scales, and new assessment methods, currently available or in development, including new scales, diagnostic criteria and new technologies such as ambulatory actigraphy. |
Databáze: | OpenAIRE |
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