Measurement of Neuropsychiatric Symptoms in Clinical Trials Targeting Alzheimer's Disease and Related Disorders

Autor: Philippe Robert, Renaud David, Emmanuel Mulin, Patrick Mallea
Rok vydání: 2010
Předmět:
Zdroj: Pharmaceuticals
Volume 3
Issue 8
Pages: 2387-2397
Pharmaceuticals, Vol 3, Iss 8, Pp 2387-2397 (2010)
ISSN: 1424-8247
DOI: 10.3390/ph3082387
Popis: Behavioral and psychological symptoms (BPSD) are now known to be frequently associated to cognitive and functional decline in Alzheimer‘s disease and related disorders. They are present since the early stages of the disease and have negative impact on the disease process. BPSD assessment is crucial in clinical practice and also in future clinical trials targeting disease-modifying therapies for dementia. In this article, we will first review current assessment tools for BPSD, mainly global and domain-specific scales, and new assessment methods, currently available or in development, including new scales, diagnostic criteria and new technologies such as ambulatory actigraphy.
Databáze: OpenAIRE