Energy Drink Administration in Combination with Alcohol Causes an Inflammatory Response and Oxidative Stress in the Hippocampus and Temporal Cortex of Rats
| Autor: | José Luis Morán-Perales, Gustavo Lopez-Lopez, Gonzalo Flores, Albino Moreno-Rodriguez, Berenice Venegas, Guadalupe Muñoz-Arenas, Samuel Treviño, Anabella Handal-Silva, Jorge Guevara, Alfonso Díaz, Patricia Aguilar-Alonso, Blanca Espinosa, Eduardo Brambila, Ulises Peña-Rosas |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Aging medicine.medical_specialty Article Subject Synaptophysin Nitric Oxide Synthase Type II medicine.disease_cause Nitric Oxide Biochemistry Hippocampus Nitric oxide Proinflammatory cytokine Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Glial Fibrillary Acidic Protein medicine Animals Energy Drinks lcsh:QH573-671 Rats Wistar chemistry.chemical_classification Temporal cortex Inflammation Reactive oxygen species Ethanol lcsh:Cytology Caspase 3 Cell Biology General Medicine medicine.disease Temporal Lobe Astrogliosis Oxidative Stress 030104 developmental biology Endocrinology chemistry Cytokines Inflammation Mediators 030217 neurology & neurosurgery Oxidative stress Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2016 (2016) |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Energy drinks (EDs) are often consumed in combination with alcohol because they reduce the depressant effects of alcohol. However, different researches suggest that chronic use of these psychoactive substances in combination with alcohol can trigger an oxidative and inflammatory response. These processes are regulated by both a reactive astrogliosis and an increase of proinflammatory cytokines such as IL-1β, TNF-α, and iNOS, causing cell death (apoptosis) at the central and peripheral nervous systems. Currently, mechanisms of toxicity caused by mixing alcohol and ED in the brain are not well known. In this study, we evaluated the effect of chronic alcohol consumption in combination with ED on inflammatory response and oxidative stress in the temporal cortex (TCx) and hippocampus (Hp) of adult rats (90 days old). Our results demonstrated that consuming a mixture of alcohol and ED for 60 days induced an increase in reactive gliosis, IL-1β, TNF-α, iNOS, reactive oxygen species, lipid peroxidation, and nitric oxide, in the TCx and Hp. We also found immunoreactivity to caspase-3 and a decrease of synaptophysin in the same brain regions. The results suggested that chronic consumption of alcohol in combination with ED causes an inflammatory response and oxidative stress, which induced cell death via apoptosis in the TCx and Hp of the adult rats. |
| Databáze: | OpenAIRE |
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